CAMKK1

Description		calcium/calmodulin dependent protein kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Intracellular Signal Transduction
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib
Diseases
GWAS		Serum alkaline phosphatase levels ( 33339817) Smoking behavior ( 19247474)
Interacting Genes		10 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 CFTR PRKAA1 SGK1 YWHAG
Entrez ID		84254
HPRD ID		13000
Ensembl ID		ENSG00000004660
Uniprot IDs		J3KPJ3 Q8N5S9
PDB IDs		6CCF 6CD6
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Transport Calcium/calmodulin-dependent Protein Kinase Activity Protein K6-linked Ubiquitination Kinase Activity Intracellular Signal Transduction ATP Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To Oxygen-containing Compound Calmodulin Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Regulation Of Developmental Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Ketone Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling TORC1 Signaling Chloride Channel Regulator Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Immune System Process Regulation Of Phosphorus Metabolic Process Nucleotide Binding Response To Alcohol Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cell Activation Negative Regulation Of TOR Signaling Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Phosphate Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Establishment Of Protein Localization Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Translational Initiation Signal Transduction Negative Regulation Of Immune Response To Tumor Cell Cellular Response To Hormone Stimulus Protein Phosphorylation Protein-containing Complex Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Stress Memory
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