SPACA1 and SMAGP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPACA1	SMAGP
Description		sperm acrosome associated 1	small cell adhesion glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle	Nucleoplasm Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Acrosome Assembly Spermatogenesis
Pathways
Drugs
Diseases
GWAS		Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)	Mean platelet volume ( 32888494)
Interacting Genes		25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47	40 interacting genes: APH1A AQP6 ARL13B ATP1B3 C2orf74 CD53 EBP ERGIC3 FAM209A FFAR2 GPX8 IL3RA JAGN1 OPRD1 OPRM1 PIGP PLPP6 PLPPR2 REEP4 RNASEK SERINC2 SGTA SLC10A6 SLC16A7 SLC71A2 SPACA1 SUSD3 TLCD4 TMEM106C TMEM14B TMEM205 TMEM234 TMEM31 TMEM45B TMEM51 TMEM80 TMPPE TMX2 UPK2 YWHAE
Entrez ID		81833	57228
HPRD ID		15419	14256
Ensembl ID		ENSG00000118434	ENSG00000170545
Uniprot IDs		Q9HBV2	Q0VAQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle	Membrane G Protein-coupled Opioid Receptor Activity Endoplasmic Reticulum G Protein-coupled Opioid Receptor Signaling Pathway
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