SPACA1 and TMEM47

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SPACA1	TMEM47
Name		sperm acrosome associated 1	transmembrane protein 47
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Acrosome Assembly Spermatogenesis	Cell-cell Adhesion
GWAS		Echocardiographic traits ( 17903301 ) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676 ) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 )	Metabolite levels ( 23823483 ) Multiple sclerosis ( 23412934 )
Interacting Genes		25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47	4 interacting genes: FAM209A SPACA1 SUSD3 TMEM179B
Entrez ID		81833	83604
HPRD ID		15419	06741
Ensembl ID		ENSG00000118434	ENSG00000147027
Uniprot IDs		Q9HBV2	Q9BQJ4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle	Inner Acrosomal Membrane Male Gamete Generation Gamete Generation Acrosomal Membrane Spermatogenesis Acrosome Assembly Secretory Granule Organization Developmental Process Involved In Reproduction Nuclear Inner Membrane Ficolin-1-rich Granule Membrane Azurophil Granule Membrane