SPACA1 and CACNG7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPACA1	CACNG7
Description		sperm acrosome associated 1	calcium voltage-gated channel auxiliary subunit gamma 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle	Early Endosome Plasma Membrane Voltage-gated Calcium Channel Complex Membrane AMPA Glutamate Receptor Complex Monoatomic Ion Channel Complex Neuronal Cell Body Cerebellar Mossy Fiber Postsynaptic Density Membrane Glutamatergic Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding Channel Regulator Activity
	Biological Process	Acrosome Assembly Spermatogenesis	Monoatomic Ion Transport Calcium Ion Transport Transmission Of Nerve Impulse Monoatomic Ion Transmembrane Transport Regulation Of MRNA Stability Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Dendrite Extension Regulation Of AMPA Receptor Activity
Pathways			Phase 0 - rapid depolarisation Phase 2 - plateau phase Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Ergocalciferol Enflurane Spironolactone Nicardipine Verapamil Efonidipine Butamben Bioallethrin
Diseases
GWAS		Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47	1 interacting genes: SPACA1
Entrez ID		81833	59284
HPRD ID		15419	06062
Ensembl ID		ENSG00000118434	ENSG00000105605
Uniprot IDs		Q9HBV2	P62955
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle	Inner Acrosomal Membrane Acrosomal Membrane Acrosome Assembly Secretory Granule Organization Acrosomal Vesicle
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