RGS18 and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 11955952)
0

Data Source:
HPRD (in vitro)

		RGS18	GNAQ
Description		regulator of G protein signaling 18	G protein subunit alpha q
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
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Diseases
GWAS		Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Food addiction ( 27106561) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		6 interacting genes: APP GNAI1 GNAI2 GNAI3 GNAQ LMNA	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		64407	2776
HPRD ID		06224	02998
Ensembl ID		ENSG00000150681	ENSG00000156052
Uniprot IDs		Q9NS28	A0A024R240 P50148
PDB IDs		2DLV 2JM5 2OWI	6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity GTP Binding Negative Regulation Of Adenylate Cyclase Activity Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Positive Regulation Of Superoxide Anion Generation Midbody G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Response To Prostaglandin E Regulation Of Superoxide Metabolic Process Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Postsynaptic Signal Transduction Glutamate Receptor Signaling Pathway Extracellular Exosome Lysosomal Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway G Protein Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway GDP Binding Cell Division Regulation Of Biological Quality Golgi Apparatus Neuropeptide Signaling Pathway Acetylcholine Receptor Activator Activity Regulation Of System Process Lipoprotein Particle Positive Regulation Of Protein Import DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Signaling Negative Regulation Of Cell Communication PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell
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