SRSF7 and CPSF6

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
HPRD (in vitro, in vivo)

		SRSF7	CPSF6
Description		serine and arginine rich splicing factor 7	cleavage and polyadenylation specific factor 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Extracellular Exosome	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane Nuclear Speck Interchromatin Granule Paraspeckles Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Ribosomal Large Subunit Binding Exon-exon Junction Complex Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	MRNA Processing MRNA 3'-end Processing Positive Regulation Of RNA Export From Nucleus Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
Drugs
Diseases
GWAS			Height ( 18391951) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Pneumoconiosis in silica exposure ( 24986923) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		20 interacting genes: CCNL2 CDK19 CDK6 CEBPA CPSF6 DUSP11 FBXO7 LUC7L LUC7L2 NEDD4 NXF1 OGT PCBP2 PRPF38A RNPS1 SDCBP SREK1 SRPK1 SRPK2 UBC	50 interacting genes: APBB1 ARMC7 CEBPA CSNK2A1 EWSR1 FOXP1 GIN1 ITCH ITSN2 KLHL12 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR155 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR25 MIR29A MIR34A MIR92A1 MIR93 MIRLET7A1 MIRLET7B MIRLET7C MIRLET7D MIRLET7F2 NCK2 NEDD4 NUDT21 OGT OTUB2 PLSCR1 PPIL1 PRPF40A SRSF7 TOLLIP UBAC1 UBQLN4 USP21 WBP4 WWOX WWP1 WWP2 YES1 ZMYND19
Entrez ID		6432	11052
HPRD ID		08991	05401
Ensembl ID		ENSG00000115875	ENSG00000111605
Uniprot IDs		C9JAB2 Q16629	Q16630
PDB IDs		2HVZ	3P5T 3P6Y 3Q2S 3Q2T 4B4N 4U0A 4U0B 4WYM 6AY9 6GX9 7SNQ 7ZUD 8CL1 8EJL 8GDV 9CNV
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nuclear Speck Nucleus RNA Binding MRNA Metabolic Process MRNA Binding MRNA Processing RNA Metabolic Process Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Splicing Protein-RNA Complex Assembly Regulation Of Cell Cycle U2-type Prespliceosome U1 SnRNP Macromolecule Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Protein Serine Kinase Activity Cyclin D2-CDK6 Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Exon-exon Junction Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Protein Targeting Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Lysosome Protein Modification Process Channel Inhibitor Activity	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Negative Regulation Of Locomotion MRNA Destabilization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Destabilization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cholesterol Efflux Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Transport Negative Regulation Of Cholesterol Transport Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
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