SRSF7 and CDK19

Number of citations of the paper that reports this interaction (PMID 12501247)
24

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		SRSF7	CDK19
Gene Name		serine/arginine-rich splicing factor 7	cyclin-dependent kinase 19
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding Poly(A) RNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome	Protein Phosphorylation Regulation Of Cell Cycle
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CCNL2 CDK19 CDK6 CPSF6 DUSP11 LUC7L2 NEDD4 NXF1 PCBP2 SDCBP SREK1 SRPK1 SRPK2	5 interactors: BCL6 EIF3F SMARCA4 SRSF7 SUZ12
Entrez ID		6432	23097
HPRD ID		08991	07627
Ensembl ID		ENSG00000115875	ENSG00000155111
Uniprot IDs		C9JAB2 Q16629	B4DUB1 Q9BWU1
PDB IDs		2HVZ
Enriched GO Terms of Interacting Partners?		RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing Gene Expression Positive Regulation Of Viral Genome Replication RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Cell Dedifferentiation Nuclear Speck Organization Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Regulation Of Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Polynucleotide 5' Dephosphorylation Cellular Nitrogen Compound Metabolic Process Nucleus Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Cellular Metabolic Process Viral Process Regulation Of Extracellular Vesicular Exosome Assembly Progesterone Receptor Signaling Pathway Regulation Of Viral Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Ribonucleoprotein Complex Assembly Cellular Protein Metabolic Process Immune Response Immune System Process Cellular Protein Modification Process Protein Phosphorylation Glucocorticoid Receptor Signaling Pathway Sperm Chromatin Condensation Poly(A)+ MRNA Export From Nucleus Negative Regulation Of Cellular Senescence Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome	Negative Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Erythrocyte Differentiation Erythrocyte Homeostasis Negative Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Myeloid Cell Homeostasis Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Negative Regulation Of Cell Growth Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Gene Expression, Epigenetic Negative Regulation Of T-helper 2 Cell Differentiation DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Homeostasis Of Number Of Cells Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Growth Myeloid Cell Differentiation Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Nucleocytoplasmic Transport Nuclear Transport RNA Metabolic Process Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Regulation Of Memory T Cell Differentiation Negative Regulation Of Cellular Senescence Negative Regulation Of Biosynthetic Process Type 2 Immune Response Regulation Of Cell Growth Positive Regulation By Host Of Viral Transcription Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Cell Aging DNA Methylation On Cytosine Regulation Of Cell Differentiation Histone Modification Negative Regulation Of Alpha-beta T Cell Differentiation Germinal Center Formation
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