HNRNPA0 and MTNR1B

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vivo)

		HNRNPA0	MTNR1B
Gene Name		heterogeneous nuclear ribonucleoprotein A0	melatonin receptor 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Nucleotide Binding RNA Binding AU-rich Element Binding Protein Kinase Binding Poly(A) RNA Binding	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Inflammatory Response RNA Splicing Gene Expression Response To Lipopolysaccharide 3'-UTR-mediated MRNA Stabilization	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Glucose Homeostasis Regulation Of Insulin Secretion
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS			Adverse response to radiation therapy ( 23719583) Diabetes (gestational) ( 22233651) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907 19060909 19651812 22508271) Glycated hemoglobin levels ( 20858683) Glycemic traits ( 23575436) Insomnia (caffeine-induced) ( 22754043) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Obesity-related traits ( 23251661) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		15 interactors: CCT3 CIRBP DDX5 HNRNPF HNRNPH2 HNRNPH3 HNRNPK IL7R MAPK6 MAPKAPK2 MTNR1A MTNR1B NKX3-1 SRSF1 U2AF2	20 interactors: CANX COPA CTNND1 FLNA GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 ITM2C MTNR1A PDIA6 PI4KA PPM1G VPS35 YWHAQ
Entrez ID		10949	4544
HPRD ID		17112	02882
Ensembl ID		ENSG00000177733	ENSG00000134640
Uniprot IDs		Q13151	P49286
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of RNA Splicing Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Gene Expression MRNA Stabilization Positive Regulation Of Gene Expression RNA Metabolic Process Termination Of RNA Polymerase II Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus MRNA Export From Nucleus Regulation Of Gene Expression DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Interleukin-7-mediated Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Androgen Secretion Regulation Of Lipid Transport Transcription From RNA Polymerase II Promoter Negative Regulation Of Estrogen Receptor Binding RNA 3'-end Processing Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus MRNA 5'-splice Site Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Nucleobase-containing Compound Metabolic Process RNA Transport Cell Growth G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macropinocytosis Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Binding	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Signaling Cell Communication Substantia Nigra Development Signal Transduction Wound Healing Vesicle-mediated Transport Neural Nucleus Development Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Stimulus Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stimulus Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Membrane Organization Response To Peptide Vesicle Organization Vesicle Fusion Regulation Of Protein Folding In Endoplasmic Reticulum Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Glucagon Positive Regulation Of Nuclease Activity Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Cyclase Activity Platelet Degranulation Secretion Cerebellum Structural Organization Negative Regulation Of Late Endosome To Lysosome Transport Organelle Fusion Cellular Response To Peptide Hormone Stimulus
Tagcloud ?		atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates posttranscriptional releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Difference) ?		atr cdc25b checkpoint chk1 contributions cytoplasm defective dissect entry feedback gadd45alpha genetics genotoxic initiate mitotic mk2 p38 parn phosphorylates posttranscriptional releases relocalizes rewire sequestration stabilization stabilize sustaining tiar unrepaired	china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants
Tagcloud (Intersection) ?