NUPR1 and ALDH1A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUPR1	ALDH1A1
Gene Name		nuclear protein, transcriptional regulator, 1	aldehyde dehydrogenase 1 family, member A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Molecular_function DNA Binding Chromatin Binding	Retinal Dehydrogenase Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Ras GTPase Activator Activity Androgen Binding Benzaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Acute Inflammatory Response Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Acetylation Male Gonad Development Response To Toxic Substance Cell Growth Positive Regulation Of Protein Modification Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Fibroblast Proliferation Regulation Of Female Gonad Development	Ethanol Oxidation Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Positive Regulation Of Ras GTPase Activity Retinol Metabolic Process Small Molecule Metabolic Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Ethanol oxidation Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations RA biosynthesis pathway Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Signaling by Retinoic Acid Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			NADH Vitamin A Tretinoin Nicotinamide-Adenine-Dinucleotide 1,4-Dithiothreitol
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		21 interactors: ABCG8 ALDH1A1 EP300 FUS KNSTRN MAPRE1 MPHOSPH6 MSL1 NACA NONO NPY5R PAXIP1 PSMD4 PTMA RAN RANBP1 RPL41 SEC11A SET STX18 SYNCRIP	4 interactors: ALDH2 BRCA1 NUPR1 POT1
Entrez ID		26471	216
HPRD ID		17814	00001
Ensembl ID		ENSG00000176046	ENSG00000165092
Uniprot IDs		O60356	P00352
PDB IDs
Enriched GO Terms of Interacting Partners?		Viral Process Gene Expression Positive Regulation Of Protein Binding Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Organelle Organization Cell Cycle Signal Transduction By P53 Class Mediator Nitrogen Compound Metabolic Process Positive Regulation Of Binding Spindle Organization Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Microtubule-based Process Nucleobase-containing Compound Metabolic Process Organelle Organization Regulation Of Histone Acetylation RNA Metabolic Process Histone H4 Acetylation Protein Localization To Organelle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Histone H2B Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Histone H3-K36 Methylation Generation Of Ovulation Cycle Rhythm Negative Regulation Of Programmed Cell Death MRNA Metabolic Process Negative Regulation Of Cell Death Peptidyl-lysine Modification Regulation Of Binding Mitotic Cell Cycle Phase Transition Intracellular Transport Cell Cycle Phase Transition Chromosome Organization Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Cellular Process Rhythmic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Nuclear Division Ribosomal Small Subunit Export From Nucleus Positive Regulation Of ER To Golgi Vesicle-mediated Transport N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Microtubule Plus-end Binding Endoplasmic Reticulum Membrane Organization Positive Regulation Of Skeletal Muscle Tissue Growth	Negative Regulation Of Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of DNA Strand Elongation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Chromosome Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Telomere Formation Via Telomerase Cellular Response To Indole-3-methanol DNA Replication Negative Regulation Of Centriole Replication Telomere Capping Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein K6-linked Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Ethanol Catabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Organelle Organization Biosynthetic Process Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Female Gonad Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Telomerase Activity Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Neurotransmitter Biosynthetic Process Regulation Of DNA Methylation
Tagcloud ?		95d altered arrest atpase c3orf1 carcinoma ccng2 col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably preliminary pten remarkably timmdc1 timp3 translocase upregulated viable	anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		95d altered arrest atpase c3orf1 carcinoma ccng2 col3a1 concurrently depleted depletion ecm focal inner introducing justified lung microarray migration mitochondrial notably preliminary pten remarkably timmdc1 timp3 translocase upregulated viable	anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?