NUPR1 and ALDH1A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NUPR1	ALDH1A1
Description		nuclear protein 1, transcriptional regulator	aldehyde dehydrogenase 1 family member A1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex Intercellular Bridge Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Axon Cell Projection Synapse Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Acetyltransferase Activator Activity	Nucleotide Binding Retinal Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity Aminobutyraldehyde Dehydrogenase (NAD+) Activity NAD Binding 3-deoxyglucosone Dehydrogenase Activity Acetaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Acute Inflammatory Response Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Assembly Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Autophagosome Assembly Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Female Gonad Development Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Retinoid Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Fructosamine Catabolic Process Maintenance Of Lens Transparency Retinol Metabolic Process Cellular Detoxification Of Aldehyde Negative Regulation Of Cold-induced Thermogenesis
Pathways			RA biosynthesis pathway Fructose catabolism Ethanol oxidation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs			NADH Vitamin A Tretinoin 1,4-Dithiothreitol
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Offspring birth weight ( 31043758) Refractive error ( 32231278) Urinary metabolite levels in chronic kidney disease ( 31959995)	Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Sensorimotor dexterity ( 31596458)
Interacting Genes		16 interacting genes: ABCG8 ALDH1A1 EP300 KNSTRN MAPRE1 MPHOSPH6 MSL1 NPY5R PAXIP1 PTMA RANBP1 RPL41 SEC11A SET STX18 SYNCRIP	4 interacting genes: ALDH2 BRCA1 NUPR1 POT1
Entrez ID		26471	216
HPRD ID		17814	00001
Ensembl ID		ENSG00000176046	ENSG00000165092
Uniprot IDs		O60356	P00352 V9HW83
PDB IDs			4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM 7JWS 7JWT 7JWU 7JWV 7JWW 7UM9 8D46 8DNO 8ENE 8PVH 8T0N 8T0T 8WFQ
Enriched GO Terms of Interacting Partners?			Regulation Of Cellular Response To Stress Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chondroitin Sulfate Proteoglycan Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Small Molecule Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of Cellular Component Organization Aldehyde Dehydrogenase [NAD(P)+] Activity Regulation Of Dopamine Biosynthetic Process Carboxylesterase Activity BRCA1-B Complex Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Receptor Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Cellular Response To Indole-3-methanol Single-stranded Telomeric DNA Binding Negative Regulation Of Centriole Replication Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Indole-3-methanol Regulation Of DNA Repair Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere Regulation Of Female Gonad Development Regulation Of Organelle Assembly BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DEAD/H-box RNA Helicase Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ethanol Metabolic Process Aldehyde Catabolic Process Aldehyde Dehydrogenase (NAD+) Activity
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