FZD6

Gene Name		frizzled class receptor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development G-protein Coupled Receptor Signaling Pathway Platelet Activation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: SFRP1 WNT4
Entrez ID		8323
HPRD ID		04559
Ensembl ID		ENSG00000164930
Uniprot IDs		B4E236 O60353
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell-matrix Adhesion Epithelial To Mesenchymal Transition Regulation Of Cell Junction Assembly Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Female Gonad Development Development Of Primary Female Sexual Characteristics Regulation Of Embryonic Development Mesenchymal Cell Development Ureteric Bud Development Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Canonical Wnt Signaling Pathway Mesonephros Development Regulation Of Osteoblast Differentiation Mesenchymal Cell Differentiation Cellular Response To Starvation Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Male Gonad Development Kidney Epithelium Development Gland Morphogenesis Tube Formation Morphogenesis Of Embryonic Epithelium Cellular Response To Nutrient Levels Response To Starvation Regulation Of Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Male Sex Differentiation Response To Transforming Growth Factor Beta Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Migration Regulation Of Ossification Positive Regulation Of Cytoskeleton Organization Mesenchyme Development Immature T Cell Proliferation In Thymus Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testicular Blood Vessel Morphogenesis
Tagcloud ?		10b 3a 5b 7a 9b affinities argues comprise dividing employ ethylmaleimide frap frizzled hardly heterotrimeric introduce minimize mobility oncogenesis originates pairings pertussis photobleaching precoupling readouts specification uncoupling wnt