FZD6 and CCDC88C

Number of citations of the paper that reports this interaction (PubMedID 26126266)
145

Data Source:
BioGRID (pull down)

		FZD6	CCDC88C
Description		frizzled class receptor 6	coiled-coil and HOOK domain protein 88C
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Apical Part Of Cell	Extracellular Region Cytoplasm Centrosome Cell Junction Apical Junction Complex Anchoring Junction
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Platelet Activation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Establishment Of Body Hair Planar Orientation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Midbrain Morphogenesis	Microtubule Bundle Formation Cilium Movement Apical Constriction Negative Regulation Of Microtubule Depolymerization Signal Transduction Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Cilium Organization Positive Regulation Of JNK Cascade Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Mucociliary Clearance Respiratory Basal Cell Differentiation
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Regulation of FZD by ubiquitination Signaling by RNF43 mutants	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Drugs
Diseases
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Daytime sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		3 interacting genes: CCDC88C SFRP1 WNT4	9 interacting genes: APP DVL1 FBXO7 FZD6 FZD7 GNAI3 ITSN2 MAPK8 MPDZ
Entrez ID		8323	440193
HPRD ID		04559	19136
Ensembl ID		ENSG00000164930	ENSG00000015133
Uniprot IDs		B4DL33 B4E236 O60353	B4DZB8 Q9P219
PDB IDs		8JH7 8JHB
Enriched GO Terms of Interacting Partners?		Frizzled Binding Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Female Gonad Development Positive Regulation Of Focal Adhesion Assembly Regulation Of Supramolecular Fiber Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Morphogenesis Of An Epithelium Kidney Epithelium Development Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cell-substrate Junction Organization Regulation Of Animal Organ Morphogenesis Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Stem Cell Differentiation Positive Regulation Of Cell Junction Assembly Regulation Of Ossification Male Gonad Development Tube Formation Negative Regulation Of Cellular Response To Growth Factor Stimulus Convergent Extension Involved In Somitogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Gonad Development Regulation Of Osteoblast Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Cell Fate Commitment Positive Regulation Of Supramolecular Fiber Organization Regulation Of Reproductive Process Regulation Of Organelle Organization Cellular Response To Starvation Nephron Morphogenesis Positive Regulation Of Glucocorticoid Biosynthetic Process	Frizzled Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Catabolic Process Canonical Wnt Signaling Pathway Collateral Sprouting Wnt Receptor Activity Neuronal Dense Core Vesicle Protein Serine/threonine Kinase Binding Apicolateral Plasma Membrane Wnt-protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Macroautophagy Neuron Projection Organization Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Activation Modulation Of Excitatory Postsynaptic Potential Wnt Signaling Pathway JUN Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Neuron Projection Regulation Of Purine Nucleotide Metabolic Process G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Presynapse Positive Regulation Of Cardiolipin Metabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import
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