FZD6 and WNT4

Number of citations of the paper that reports this interaction (PMID 15265686)
36

Data Source:
HPRD (in vivo)

		FZD6	WNT4
Gene Name		frizzled class receptor 6	wingless-type MMTV integration site family, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Transcription Corepressor Activity Frizzled Binding Receptor Agonist Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development G-protein Coupled Receptor Signaling Pathway Platelet Activation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Androgen Biosynthetic Process Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Protein Palmitoylation Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Dupuytren's disease ( 21732829) Endometriosis ( 23104006 23472165 20601957) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: SFRP1 WNT4	6 interactors: APP FZD6 P2RX4 PORCN SFRP1 SFRP2
Entrez ID		8323	54361
HPRD ID		04559	04601
Ensembl ID		ENSG00000164930	ENSG00000162552
Uniprot IDs		B4E236 O60353	B4DJF9 P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell-matrix Adhesion Epithelial To Mesenchymal Transition Regulation Of Cell Junction Assembly Regulation Of Stress Fiber Assembly Canonical Wnt Signaling Pathway Female Gonad Development Development Of Primary Female Sexual Characteristics Regulation Of Embryonic Development Mesenchymal Cell Development Ureteric Bud Development Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Canonical Wnt Signaling Pathway Mesonephros Development Regulation Of Osteoblast Differentiation Mesenchymal Cell Differentiation Cellular Response To Starvation Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Male Gonad Development Kidney Epithelium Development Gland Morphogenesis Tube Formation Morphogenesis Of Embryonic Epithelium Cellular Response To Nutrient Levels Response To Starvation Regulation Of Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Male Sex Differentiation Response To Transforming Growth Factor Beta Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Migration Regulation Of Ossification Positive Regulation Of Cytoskeleton Organization Mesenchyme Development Immature T Cell Proliferation In Thymus Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Testicular Blood Vessel Morphogenesis	Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Wnt Signaling Pathway Cellular Response To X-ray Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Involved In Somitogenesis Neural Tube Closure Neural Tube Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of JUN Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Developmental Growth Involved In Morphogenesis Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Cell Surface Receptor Signaling Pathway Tube Formation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Canonical Wnt Signaling Pathway Response To X-ray Negative Regulation Of JNK Cascade Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Stress-activated MAPK Cascade Developmental Growth Axis Elongation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Fat Cell Differentiation Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Ionizing Radiation Tube Morphogenesis Regulation Of Signal Transduction Signal Transduction Digestive Tract Morphogenesis Response To Radiation
Tagcloud ?		10b 3a 5b 7a 9b affinities argues comprise dividing employ ethylmaleimide frap frizzled hardly heterotrimeric introduce minimize mobility oncogenesis originates pairings pertussis photobleaching precoupling readouts specification uncoupling wnt	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		10b 3a 5b 7a 9b affinities argues comprise dividing employ ethylmaleimide frap hardly heterotrimeric introduce minimize mobility oncogenesis originates pairings pertussis photobleaching precoupling readouts specification uncoupling wnt	abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?		frizzled