MMS19 and GTF2H1

Number of citations of the paper that reports this interaction (PMID 11071939)
6

Data Source:
HPRD (in vitro, in vivo)

		MMS19	GTF2H1
Gene Name		MMS19 nucleotide excision repair homolog (S. cerevisiae)	general transcription factor IIH, polypeptide 1, 62kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Spindle Membrane MMXD Complex CIA Complex	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Receptor Signaling Complex Scaffold Activity Estrogen Receptor Binding Protein Binding, Bridging	Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Phosphorelay Signal Transduction System DNA Metabolic Process DNA Repair Nucleotide-excision Repair Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromosome Segregation Response To Hormone Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Cytosolic iron-sulfur cluster assembly	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Amyloid A Levels ( 21124955) Pancreatic cancer ( 23180869)
Protein-Protein Interactions		6 interactors: ESR1 ESR2 GTF2H1 NCOA3 RARA THRB	42 interactors: ACTN1 AR ATF7IP BRPF1 CCNH CCSER2 CDK7 CTD E2F1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FUBP1 GTF2E1 GTF2E2 GTF2H2 GTF2H3 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 USHBP1 XPA XPC ZSCAN1
Entrez ID		64210	2965
HPRD ID		17579	01807
Ensembl ID		ENSG00000155229	ENSG00000110768
Uniprot IDs		Q96T76	P32780
PDB IDs			1PFJ 2DII 2RNR
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Vagina Development Steroid Hormone Mediated Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Female Genitalia Development Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Genitalia Development Sex Differentiation Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Hormone Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To Organic Cyclic Compound RNA Biosynthetic Process Epithelium Development Cellular Response To Lipid Response To Steroid Hormone Gland Development Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium Reproductive Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Uterus Development Gland Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Morphogenesis Gene Expression Tube Development Tissue Development Developmental Process Involved In Reproduction Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gonad Development Cellular Response To Organic Substance Development Of Primary Sexual Characteristics	Nucleotide-excision Repair, DNA Damage Removal Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription-coupled Nucleotide-excision Repair Viral Process Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter DNA Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Gene Expression Transcription Elongation From RNA Polymerase I Promoter Nitrogen Compound Metabolic Process DNA Repair Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Viral Process DNA Metabolic Process RNA Metabolic Process Cellular Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Response To Stress
Tagcloud ?		ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6
Tagcloud (Difference) ?		ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6
Tagcloud (Intersection) ?