MMS19 and NCOA3

Number of citations of the paper that reports this interaction (PMID 11279242)
21

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MMS19	NCOA3
Gene Name		MMS19 nucleotide excision repair homolog (S. cerevisiae)	nuclear receptor coactivator 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Spindle Membrane MMXD Complex CIA Complex	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Receptor Signaling Complex Scaffold Activity Estrogen Receptor Binding Protein Binding, Bridging	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Phosphorelay Signal Transduction System DNA Metabolic Process DNA Repair Nucleotide-excision Repair Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromosome Segregation Response To Hormone Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Multicellular Organism Growth Receptor Transactivation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Vagina Development Labyrinthine Layer Morphogenesis Mammary Gland Branching Involved In Thelarche Regulation Of RNA Biosynthetic Process
Pathways		Cytosolic iron-sulfur cluster assembly	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Response to treatment for acute lymphoblastic leukemia ( 19176441)
Protein-Protein Interactions		6 interactors: ESR1 ESR2 GTF2H1 NCOA3 RARA THRB	77 interactors: ABL1 ANKRD11 AR ARNT2 ATAD2 BMP6 BMP7 BRCA1 BRE CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B HIST3H3 HIST4H4 IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		64210	8202
HPRD ID		17579	03570
Ensembl ID		ENSG00000155229	ENSG00000124151
Uniprot IDs		Q96T76	Q0IIN7 Q59EE8 Q9Y6Q9
PDB IDs			1KBH 3L3X 3L3Z
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Vagina Development Steroid Hormone Mediated Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Female Genitalia Development Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Genitalia Development Sex Differentiation Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Hormone Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To Organic Cyclic Compound RNA Biosynthetic Process Epithelium Development Cellular Response To Lipid Response To Steroid Hormone Gland Development Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium Reproductive Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Uterus Development Gland Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Morphogenesis Gene Expression Tube Development Tissue Development Developmental Process Involved In Reproduction Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gonad Development Cellular Response To Organic Substance Development Of Primary Sexual Characteristics	Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Steroid Hormone Response To Lipid Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Regulation Of Gene Expression Response To Hormone Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of RNA Biosynthetic Process Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Communication Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?		ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?