SEPP1 and THRA

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		SEPP1	THRA
Gene Name		selenoprotein P, plasma, 1	thyroid hormone receptor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Selenium Binding	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding
	Biological Process	Selenium Compound Metabolic Process Response To Oxidative Stress Brain Development Locomotory Behavior Post-embryonic Development Sexual Reproduction Growth	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS			White blood cell count ( 21738480)
Protein-Protein Interactions		4 interactors: EGFR EP300 MEOX2 THRA	56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3
Entrez ID		6414	7067
HPRD ID		03286	07185
Ensembl ID		ENSG00000250722	ENSG00000126351
Uniprot IDs		P49908	P10827 Q6FH41
PDB IDs			1NAV 2H77 2H79 3HZF 3ILZ 3JZB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Development Epithelium Development Respiratory Tube Development Respiratory System Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Development Response To Steroid Hormone Regulation Of Transcription From RNA Polymerase II Promoter Somitogenesis Somite Development Tube Development Anatomical Structure Morphogenesis Chordate Embryonic Development Segmentation Positive Regulation Of Cellular Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Histone H2B Acetylation Alkanesulfonate Metabolic Process Response To Lipid Skeletal Muscle Tissue Development Response To Organic Cyclic Compound Skeletal Muscle Organ Development Response To Hormone Organ Development Organ Morphogenesis Regulation Of Protein Import Into Nucleus Circadian Rhythm Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Astrocyte Activation Cellular Response To Steroid Hormone Stimulus Response To Temperature Stimulus Response To Abiotic Stimulus Regulation Of Protein Localization To Nucleus Embryo Development Positive Regulation Of Metabolic Process Regulation Of Nucleocytoplasmic Transport Response To Estrogen Gene Expression Positive Regulation Of Female Receptivity N-terminal Peptidyl-lysine Acetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription, Initiation Activation Of Phospholipase A2 Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development
Tagcloud ?		aaa aaas aiod aneurysm aortic aortoiliac bmi carriers causality coexistence consider depending haplotype inadequate influenced occlusive overweight pad pulse recessive rs3877899a rs3877899g rs7579g selenium selenoprotein strongest supposed systolic variants	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Difference) ?		aaa aaas aiod aneurysm aortic aortoiliac bmi carriers causality coexistence consider depending haplotype inadequate influenced occlusive overweight pad pulse recessive rs3877899a rs3877899g rs7579g selenium selenoprotein strongest supposed systolic variants	accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate
Tagcloud (Intersection) ?