TINAGL1 and PITX2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TINAGL1	PITX2
Name		tubulointerstitial nephritis antigen like 1	paired like homeodomain 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Extracellular Matrix Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Cysteine-type Peptidase Activity Laminin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Endosomal Transport	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Outflow Tract Morphogenesis Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Heart Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Pituitary Gland Development Lung Development Regulation Of Cell Migration Embryonic Camera-type Eye Development Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Associated Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Regulation Of Cell Population Proliferation Odontogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Embryonic Digestive Tract Morphogenesis System Development Cardiac Muscle Tissue Development Cardiac Muscle Cell Differentiation Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Digestive System Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification
Pathways		None	TFAP2 (AP-2) family regulates transcription of other transcription factors
Diseases		None	Axenfeld-Rieger syndrome (ARS)
GWAS		Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )	Appendectomy ( 30392061 ) Atrial fibrillation ( 19597492 33990960 30061737 29892015 29290336 28416822 28416818 20173747 22544366 ) Atrial fibrillation/atrial flutter ( 17603472 ) Cardioembolic stroke (CCS and TOAST classification) ( 32047268 ) Cardioembolic stroke (CCS or TOAST classification) ( 32047268 ) Cardioembolic stroke (CCSc classification) ( 32047268 ) Cardioembolic stroke (CCSp classification) ( 32047268 ) Cardioembolic stroke (TOAST classification) ( 32047268 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Early onset atrial fibrillation ( 28460022 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Glaucoma (primary open-angle) ( 33627673 ) Heart failure ( 31919418 ) Incident atrial fibrillation ( 28416818 ) Intraocular pressure ( 29235454 ) Ischemic stroke ( 24262325 26708676 ) Ischemic stroke (cardioembolic) ( 26708676 27068588 ) Lung cancer ( 28604730 ) Prevalent atrial fibrillation ( 28416818 ) Sick sinus syndrome ( 33580673 ) Smoking status (heavy vs never) ( 26423011 ) Stroke (ischemic) ( 23041239 )
Novel Interactors		None recorded	1 novel interactors: SLAMF7
Interacting Genes		18 interacting genes: BAG4 CAPN1 EP300 KRTAP10-3 KRTAP12-2 KRTAP4-2 LMO4 MDFI MED31 MTDH NOTCH2NLA PITX2 PROP1 RBPMS SHBG SMAD9 TRIP13 UTP14A	36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SPMIP9 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3
Entrez ID		64129	5308
HPRD ID		07122	03328
Ensembl ID		ENSG00000142910	ENSG00000164093
Uniprot IDs		F6SDV2 Q9GZM7	Q99697
PDB IDs		Not available	2L7F 2L7M 2LKX
GO Terms Enriched among Interactors		Transcription Coregulator Activity Transcription Regulator Complex Somatotropin Secreting Cell Differentiation Pre-mRNA Intronic Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Peptidyl-lysine Propionylation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Fate Commitment Swimming Positive Regulation Of RNA Metabolic Process Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Metabolic Process NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SMAD Protein Signal Transduction Pituitary Gland Development Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of MRNA Modification Intermediate Filament Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Histone H2B Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Peptide 2-hydroxyisobutyryltransferase Activity Cell Differentiation Regulation Of Transcription By RNA Polymerase II Protein Propionyltransferase Activity Negative Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis	Transcription Coactivator Activity Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Fungiform Papilla Formation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Hair Follicle Placode Formation Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Odontoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin-TCF Complex Maintenance Of Cell Polarity Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Epithelial To Mesenchymal Transition Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Stress Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Odontogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Binding Mesenchymal Cell Differentiation Host-mediated Perturbation Of Symbiont Process