MAGEF1 and TRAIP

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (two hybrid)

		MAGEF1	TRAIP
Description		MAGE family member F1	TRAF interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm Site Of DNA Damage
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	DNA Repair Apoptotic Process DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Replication Fork Processing Negative Regulation Of Interferon-beta Production Protein-DNA Covalent Cross-linking Repair
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Nose size ( 27182965)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mental health study participation (provided email address) ( 31263887) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: MDFI MMS19 NSMCE1 PHF7 TRAIP TRIM27	29 interacting genes: ALOX15B APP CEP19 CYLD FLII LXN MAGEF1 MAPRE2 MAPRE3 POLK POLR1C RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 UIMC1 USP2
Entrez ID		64110	10293
HPRD ID		14348	05811
Ensembl ID		ENSG00000177383	ENSG00000183763
Uniprot IDs		Q9HAY2	Q9BWF2
PDB IDs			4ZTD
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Sumoylation Ubiquitin-protein Transferase Activity Negative Regulation Of Type I Interferon Production DNA Repair Post-translational Protein Modification Zinc Ion Binding Regulation Of Type I Interferon Production Transferase Activity Protein Modification By Small Protein Conjugation DNA Metabolic Process DNA Damage Response Negative Regulation Of Osteoclast Proliferation Cytosolic [4Fe-4S] Assembly Targeting Complex MMXD Complex Phosphatidylinositol 3-kinase Inhibitor Activity Nucleus Protein-DNA Covalent Cross-linking Repair Nucleoplasm Smc5-Smc6 Complex Transcription Coactivator Activity Positive Regulation Of Actin Nucleation Transcription Factor TFIIH Holo Complex Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Negative Regulation Of Cytokine Production Negative Regulation Of Viral Transcription Negative Regulation Of Interferon-beta Production Chromatin Looping Suppression Of Viral Release By Host Arp2/3 Complex-mediated Actin Nucleation Regulation Of Viral Transcription SUMO Transferase Activity Retromer Complex	Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Autoubiquitination Tumor Necrosis Factor Receptor Superfamily Complex Catabolic Process Protein K11-linked Ubiquitination Microtubule End Tumor Necrosis Factor Binding Cell Death Programmed Cell Death Cytoplasmic Microtubule Thioesterase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Protein Localization To Microtubule Positive Regulation Of Membrane Protein Ectodomain Proteolysis Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Nucleus Protein Catabolic Process Apoptotic Process Programmed Necrotic Cell Death Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding Nucleoplasm Microtubule Plus-end
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