PBLD and EFHC2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PBLD	EFHC2
Gene Name		phenazine biosynthesis-like protein domain containing	EF-hand domain (C-terminal) containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding Isomerase Activity	Calcium Ion Binding
	Biological Process	Biosynthetic Process Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways
Drugs
Diseases
GWAS		Optic disc parameters ( 20548946) Optic disc size (disc) ( 20395239) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		7 interactors: CCDC184 EFHC2 LNX1 STRAP TCF4 TRIP13 UBC	30 interactors: ARHGEF5 ARMC7 CCDC120 CCHCR1 CCNG2 CLIC3 COPE CYFIP1 DGCR6 EDC3 EGLN3 EMD EXOC8 JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 PBLD PLOD3 PTK6 RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4
Entrez ID		64081	80258
HPRD ID		14366	06540
Ensembl ID		ENSG00000108187
Uniprot IDs		C9JIM0 P30039	Q5JST6
PDB IDs			2Z13 2Z14
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Polysaccharide Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Response To Transforming Growth Factor Beta Negative Regulation Of Wnt Signaling Pathway Hexose Metabolic Process Cell Cycle Process Maintenance Of DNA Repeat Elements DNA-templated Transcription, Initiation DNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Signal Transduction Cellular Carbohydrate Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Hindgut Morphogenesis Embryonic Genitalia Morphogenesis Regulation Of Epithelial Cell Proliferation RNA Metabolic Process Myoblast Fate Commitment Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Secretory Granule Localization Gene Expression	Regulation Of Podosome Assembly
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