CDH23 and MYO7A

Number of citations of the paper that reports this interaction (PMID 12485990)
106

Data Source:
HPRD (in vitro)

		CDH23	MYO7A
Gene Name		cadherin-related 23	myosin VIIA
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Stereocilium	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cell Cortex Apical Plasma Membrane Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse
	Molecular Function	Calcium Ion Binding Protein Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Protein Homodimerization Activity ADP Binding Actin Filament Binding
	Biological Process	Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Photoreceptor Cell Maintenance Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Cytosolic Calcium Ion Homeostasis	Phagolysosome Assembly Intracellular Protein Transport Lysosome Organization Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Eye Photoreceptor Cell Development Post-embryonic Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways			Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction
Drugs
Diseases
GWAS		Vitiligo ( 22951725)
Protein-Protein Interactions		2 interactors: MYO7A USH1C	11 interactors: ACTA1 CALM1 CDH23 DFNB31 KEAP1 KHDRBS1 MAP2 MYRIP PRKAR1A USH1C VEZT
Entrez ID		64072	4647
HPRD ID		05699	02043
Ensembl ID		ENSG00000107736	ENSG00000137474
Uniprot IDs		A5D6V9 Q6P152 Q8N5B3 Q9H251	B9A012 Q13402
PDB IDs		2KBR 2KBS 2LSR
Enriched GO Terms of Interacting Partners?		Equilibrioception Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Neuromuscular Process Controlling Balance Inner Ear Morphogenesis Ear Morphogenesis Neuromuscular Process Epidermal Cell Differentiation Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Inner Ear Development Ear Development Epidermis Development Parallel Actin Filament Bundle Assembly Embryonic Organ Morphogenesis Embryonic Organ Development Epithelial Cell Differentiation Sensory Organ Development Post-embryonic Organ Morphogenesis Auditory Receptor Cell Stereocilium Organization Embryonic Morphogenesis Actin Filament-based Process Auditory Receptor Cell Morphogenesis Phagolysosome Assembly Sensory Perception Auditory Receptor Cell Development Inner Ear Receptor Stereocilium Organization Organ Morphogenesis Epithelium Development Neuron Differentiation Embryo Development Neurological System Process Photoreceptor Cell Maintenance Pigment Granule Transport Eye Photoreceptor Cell Development Inner Ear Receptor Cell Development Phagosome Maturation Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation Generation Of Neurons Lysosome Organization Neurogenesis Retina Homeostasis Cellular Pigmentation Actin Filament-based Movement Tissue Development Actin Filament Bundle Assembly	Retina Homeostasis Equilibrioception Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Tissue Homeostasis Photoreceptor Cell Maintenance Multicellular Organismal Homeostasis Multicellular Organismal Development Activation Of Phospholipase C Activity Anatomical Structure Development Positive Regulation Of Phospholipase C Activity Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Myofibril Assembly Positive Regulation Of Phospholipase Activity Neuromuscular Process Controlling Balance Developmental Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Positive Regulation Of RNA Export From Nucleus Skeletal Muscle Fiber Adaptation Parallel Actin Filament Bundle Assembly Actomyosin Structure Organization Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Embryo Development G2/M Transition Of Mitotic Cell Cycle Neuromuscular Process Positive Regulation Of Protein Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Striated Muscle Cell Development Regulation Of High Voltage-gated Calcium Channel Activity Actin Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Muscle Cell Development Fibroblast Growth Factor Receptor Signaling Pathway Homeostatic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Actin Filament-based Process Skeletal Muscle Thin Filament Assembly Inner Ear Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organic Substance Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		alters annotation ca3 candidate dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Difference) ?		alters annotation ca3 candidate dataset disequilibrium ear fdr filtering harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Intersection) ?		gwas