CDH23

Description		cadherin related 23
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Centrosome Plasma Membrane Membrane Catenin Complex Stereocilium Stereocilium Tip Synapse Kinocilium Cochlear Hair Cell Ribbon Synapse Photoreceptor Ribbon Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Calcium Ion Transport Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Locomotory Behavior Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Neuron Projection Development Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Photoreceptor Cell Maintenance Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Regulation Of Cytosolic Calcium Ion Concentration Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Deafness, autosomal recessive Usher syndrome (US)
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Age-related hearing impairment ( 34108613) Bipolar disorder (body mass index interaction) ( 24322204) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cognitive performance (processing speed) ( 31598132) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Kidney function decline traits ( 25493955) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Progranulin levels ( 29186428) Selective IgA deficiency ( 27723758) Self-reported risk-taking behaviour ( 30271922) Systemic lupus erythematosus ( 33272962 33536424) Vitiligo ( 22951725)
Interacting Genes		3 interacting genes: CLK1 MYO7A USH1C
Entrez ID		64072
HPRD ID		05699
Ensembl ID		ENSG00000107736
Uniprot IDs		A0A087WYR8 A5D6V9 Q6P152 Q8N5B3 Q9H251
PDB IDs		2KBR 2KBS 2LSR 5TFM 5VVM 5WJ8
Enriched GO Terms of Interacting Partners?		Equilibrioception Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Spectrin Binding Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Eye Photoreceptor Cell Development Inner Ear Receptor Cell Stereocilium Organization Photoreceptor Cell Development Stereocilium Photoreceptor Inner Segment Inner Ear Morphogenesis Microvillus Photoreceptor Outer Segment Epidermal Cell Differentiation Upper Tip-link Density Myosin VII Complex Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Neuron Development Protein Localization To Microvillus Sensory Perception Of Light Stimulus Phagolysosome Assembly Stereocilium Base Actin Filament Organization Brush Border Assembly Regulation Of Microvillus Length Stereocilia Ankle Link Complex Auditory Receptor Cell Morphogenesis Parallel Actin Filament Bundle Assembly Neuron Differentiation Photoreceptor Cell Cilium Epithelial Cell Differentiation Embryonic Morphogenesis Retinal Cone Cell Development Regulation Of Cell Projection Size Sensory Perception Neuron Projection Development Supramolecular Fiber Organization Stereocilium Tip Auditory Receptor Cell Stereocilium Organization Cell Morphogenesis Involved In Neuron Differentiation Pigment Granule Transport Pigment Granule Localization Protein Serine/threonine/tyrosine Kinase Activity Microfilament Motor Activity Cochlea Development ADP Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Photoreceptor Connecting Cilium
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