REG3A and TRHDE

Number of citations of the paper that reports this interaction (PubMedID 10662590)
0

Data Source:
HPRD (two hybrid, in vitro)

		REG3A	TRHDE
Description		regenerating family member 3 alpha	thyrotropin releasing hormone degrading enzyme
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Peptidoglycan Binding Oligosaccharide Binding	Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Pyroglutamyl-peptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Acute-phase Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Response To Symbiotic Bacterium Response To Wounding Positive Regulation Of Keratinocyte Proliferation Response To Peptide Hormone Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Detection Of Glucose	Proteolysis Signal Transduction Cell-cell Signaling Peptide Catabolic Process
Pathways		Antimicrobial peptides
Drugs
Diseases
GWAS		Body mass index ( 25673413) HDL cholesterol levels in HIV infection ( 33109212)	Chemerin levels ( 20237162) Diastolic blood pressure ( 26969751) General risk tolerance (MTAG) ( 30643258) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Rheumatoid arthritis ( 21452313) Tea consumption ( 31046077)
Interacting Genes		6 interacting genes: ANXA3 FN1 MDFI REG1A SDC2 TRHDE	1 interacting genes: REG3A
Entrez ID		5068	29953
HPRD ID		01342	09506
Ensembl ID		ENSG00000172016	ENSG00000072657
Uniprot IDs		Q06141 Q53S56	Q9UKU6
PDB IDs		1UV0 2GO0 4MTH
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Detection Of Glucose Response To Symbiotic Bacterium Response To Symbiont Inflammatory Response To Wounding Regulation Of Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding Oligosaccharide Binding Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Epidermal Cell Differentiation Peptidoglycan Binding Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Cytokine Production Involved In Inflammatory Response Acute-phase Response Regulation Of Keratinocyte Differentiation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Regulation Of Keratinocyte Proliferation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Wound Healing Regulation Of Epidermal Cell Differentiation Regulation Of Epidermis Development Acute Inflammatory Response Regulation Of Cytokine Production Involved In Inflammatory Response Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Wound Healing Antimicrobial Humoral Response Regulation Of Epithelial Cell Differentiation Carbohydrate Binding Regulation Of Response To Wounding Negative Regulation Of Inflammatory Response Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Wounding Humoral Immune Response Signaling Receptor Activity Negative Regulation Of Defense Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone
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