ASB11 and CUL5

Number of citations of the paper that reports this interaction (PubMedID 31387940)
57

Data Source:
BioGRID (pull down)

		ASB11	CUL5
Description		ankyrin repeat and SOCS box containing 11	cullin 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Cul5-RING Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Ubiquitin-like Ligase-substrate Adaptor Activity	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Signal Transduction Proteasomal Protein Catabolic Process Negative Regulation Of Epithelial To Mesenchymal Transition Cell Migration Protein Ubiquitination Layer Formation In Cerebral Cortex Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Reelin-mediated Signaling Pathway ERBB2 Signaling Pathway Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Defense Response To Virus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Symbiont-mediated Suppression Of Host Innate Immune Response Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Calcium Ion Transmembrane Transport Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Focal Adhesion Disassembly CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Neuron Migration
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS		vascular endothelial growth factor D levels ( 25147954)	Refractive error ( 32231278)
Interacting Genes		7 interacting genes: BIK CUL5 ELOB ELOC PAICS RNF7 UBC	41 interacting genes: ANAPC11 APOBEC3C APOBEC3G ASB11 CCNB1IP1 CCNDBP1 CKB COG6 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DEPTOR ELOA ELOC ERCC6 GHR GOLGA2 GPS1 KANK4 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBA3 UBC UBE2L3 VHL
Entrez ID		140456	8065
HPRD ID		06450	03444
Ensembl ID		ENSG00000165192	ENSG00000166266
Uniprot IDs		Q8WXH4	Q93034
PDB IDs		4UUC	3DPL 3DQV 4JGH 4N9F 6V9I 7ONI 8EI2 8FVI 8FVJ
Enriched GO Terms of Interacting Partners?		Cul5-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Focal Adhesion Disassembly Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway MiRNA Catabolic Process Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Macromolecule Catabolic Process Negative Regulation Of MiRNA-mediated Gene Silencing Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul2-RING Ubiquitin Ligase Complex Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Modification-dependent Protein Catabolic Process MiRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein Modification Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Neuron Migration Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly DNA-templated Transcription Initiation Regulation Of Cell-substrate Junction Organization Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Epithelial To Mesenchymal Transition Proteolysis Mesenchymal Cell Differentiation Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Junction Assembly Symbiont-mediated Suppression Of Host Innate Immune Response	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Deneddylation Regulation Of Protein Neddylation Protein Modification Process Regulation Of Post-translational Protein Modification COP9 Signalosome Regulation Of Protein Modification Process Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteolysis Nucleoplasm Cytosol NEDD8 Transferase Activity Cullin Family Protein Binding Macromolecule Catabolic Process Regulation Of Primary Metabolic Process Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Nucleus I-SMAD Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Protein Ubiquitination Ubiquitin Protein Ligase Binding Cul2-RING Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of TORC1 Signaling Elongin Complex Ubiquitin-protein Transferase Activity NEDD8 Ligase Activity COP9 Signalosome Assembly Cytoplasm Endosome Membrane Negative Regulation Of TOR Signaling Phosphocreatine Biosynthetic Process DeNEDDylase Activity Regulation Of Metabolic Process
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