CXCL11 and CCL8

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CXCL11	CCL8
Description		C-X-C motif chemokine ligand 11	C-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Positive Regulation Of Leukocyte Migration Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Myoblast Differentiation Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Myoblast Fusion
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Pidolic acid
Diseases
GWAS		Blood protein levels ( 30072576) Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Blood protein levels ( 30072576) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		25 interacting genes: CCL1 CCL11 CCL13 CCL20 CCL21 CCL24 CCL25 CCL26 CCL5 CCL8 CCR3 CXCL10 CXCL12 CXCL14 CXCL2 CXCL9 CXCR3 DPP4 LRRK2 MTUS2 PF4 PF4V1 PPBP SMARCB1 XCL1	20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2
Entrez ID		6373	6355
HPRD ID		05329	03791
Ensembl ID		ENSG00000169248	ENSG00000108700
Uniprot IDs		O14625	P80075
PDB IDs		1RJT 8HNK	1ESR 7S59 7S5A
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Migration Granulocyte Migration Cell Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Cell Motility Inflammatory Response Cell Killing CCR Chemokine Receptor Binding Defense Response Eosinophil Chemotaxis Defense Response To Symbiont Eosinophil Migration Defense Response To Other Organism Immune Response Cytokine-mediated Signaling Pathway Immune System Process Response To Other Organism Extracellular Space Response To External Biotic Stimulus Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Response To Stress CXCR Chemokine Receptor Binding Positive Regulation Of Locomotion Extracellular Region Mononuclear Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Motility Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Cell Migration Inflammatory Response Leukocyte Chemotaxis Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Leukocyte Migration Antimicrobial Humoral Response Immune Response Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Cytokine Activity Defense Response Humoral Immune Response Immune System Process Granulocyte Chemotaxis Granulocyte Migration C-C Chemokine Binding Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Extracellular Space Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Response To Stress Response To Other Organism Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Calcium-mediated Signaling Response To Lipopolysaccharide Regulation Of Cell Migration
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