CXCL11 and CXCR3

Number of citations of the paper that reports this interaction (PMID 9625760)
113

Data Source:
HPRD (in vivo, in vitro)

		CXCL11	CXCR3
Gene Name		chemokine (C-X-C motif) ligand 11	chemokine (C-X-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-X-C Chemokine Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Leukocyte Migration Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation T Cell Chemotaxis Negative Regulation Of Angiogenesis Calcium-mediated Signaling Positive Regulation Of CAMP Metabolic Process Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 11 Production Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CCR3 CXCR3 DPP4 MTUS2	6 interactors: CXCL10 CXCL11 CXCL13 CXCL9 PF4 VCAN
Entrez ID		6373	2833
HPRD ID		05329	02936
Ensembl ID		ENSG00000169248	ENSG00000186810
Uniprot IDs		O14625	P49682
PDB IDs		1RJT
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Angiogenesis Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotion Cytosolic Calcium Ion Homeostasis Chemokine (C-C Motif) Ligand 11 Production Regulation Of Cell Proliferation Regulation Of Angiogenesis Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Negative Regulation Of Execution Phase Of Apoptosis Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Metal Ion Homeostasis Chemokine Production Cellular Chemical Homeostasis Positive Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Positive Regulation Of CAMP-mediated Signaling Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Chemotaxis T Cell Migration Cellular Homeostasis Response To Cytokine Regulation Of CAMP-mediated Signaling Regulation Of Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Migration Lymphocyte Migration Regulation Of Extracellular Matrix Disassembly Chemical Homeostasis Negative Regulation Of Endothelial Cell Proliferation Cell Motility Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Extracellular Matrix Organization Regulation Of Cell Adhesion Mediated By Integrin Cellular Defense Response	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of CAMP-mediated Signaling Lymphocyte Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of CAMP-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Lymphocyte Migration Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior Leukocyte Migration T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Cell Migration Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Lipopolysaccharide Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of CAMP Metabolic Process T Cell Migration Inflammatory Response Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Locomotion Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipid Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Calcium Ion Transport G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		academic assessing auc bacilli centre chemoattractant cxcl9 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Difference) ?		academic assessing auc bacilli centre chemoattractant cxcl9 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	allergic cc ccr1 ccr3 ccr4 ccr5 chemokine chemokines coreceptors cxcr1 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Intersection) ?		cxcr3