CXCL11 and CCR3

Number of citations of the paper that reports this interaction (PMID 11110785)
48

Data Source:
HPRD (in vitro)

		CXCL11	CCR3
Gene Name		chemokine (C-X-C motif) ligand 11	chemokine (C-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CXCR3 Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CCR3 CXCR3 DPP4 MTUS2	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6373	1232
HPRD ID		05329	03167
Ensembl ID		ENSG00000169248	ENSG00000183625
Uniprot IDs		O14625	P51677 Q8TDP4 Q8TDP5
PDB IDs		1RJT
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Angiogenesis Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotion Cytosolic Calcium Ion Homeostasis Chemokine (C-C Motif) Ligand 11 Production Regulation Of Cell Proliferation Regulation Of Angiogenesis Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Negative Regulation Of Execution Phase Of Apoptosis Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Chemotaxis Metal Ion Homeostasis Chemokine Production Cellular Chemical Homeostasis Positive Regulation Of Execution Phase Of Apoptosis Ion Homeostasis Positive Regulation Of CAMP-mediated Signaling Cellular Response To Cytokine Stimulus Chemotaxis Lymphocyte Chemotaxis T Cell Migration Cellular Homeostasis Response To Cytokine Regulation Of CAMP-mediated Signaling Regulation Of Execution Phase Of Apoptosis Response To Stress Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Migration Lymphocyte Migration Regulation Of Extracellular Matrix Disassembly Chemical Homeostasis Negative Regulation Of Endothelial Cell Proliferation Cell Motility Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Extracellular Matrix Organization Regulation Of Cell Adhesion Mediated By Integrin Cellular Defense Response	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		academic assessing auc bacilli centre chemoattractant cxcl9 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		academic assessing auc bacilli centre cxcl9 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	basophil basophils c5a ccr2 chains chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?		chemoattractant