ACKR1 and CD48

		ACKR1	CD48
Description		atypical chemokine receptor 1 (Duffy blood group)	CD48 molecule
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Recycling Endosome	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Chemokine Binding C-C Chemokine Binding Signaling Receptor Activity	Protein Binding Receptor Ligand Activity
	Biological Process	Defense Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation
Pathways		Peptide ligand-binding receptors	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		2532	962
HPRD ID		00192	00177
Ensembl ID		ENSG00000213088	ENSG00000117091
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	A0A087X1S7 P09326
PDB IDs		4NUU 4NUV 7P93 8A44 8JPS	2EDO
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Inflammatory Response Leukocyte Chemotaxis Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response To Symbiont Defense Response To Other Organism Defense Response CCR Chemokine Receptor Binding Leukocyte Migration Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Response To Other Organism Immune System Process Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway Extracellular Region Regulation Of Leukocyte Migration Chemokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Leukocyte Chemotaxis Monocyte Chemotaxis Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Killing Of Cells Of Another Organism Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Signal Transduction Positive Regulation Of Chemotaxis Response To Fibroblast Growth Factor CCR2 Chemokine Receptor Binding Response To Stress Cell Killing Cellular Response To Interleukin-1 Regulation Of Granulocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process
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