ACKR1 and CCL2

Number of citations of the paper that reports this interaction (PMID 17416748)
21

Data Source:
HPRD (in vivo, in vitro)

		ACKR1	CCL2
Gene Name		atypical chemokine receptor 1 (Duffy blood group)	chemokine (C-C motif) ligand 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Endocytic Vesicle Dendrite Perikaryon Axon Terminus C-fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity C-C Chemokine Binding	Protein Kinase Activity Receptor Binding Chemokine Activity Heparin Binding CCR2 Chemokine Receptor Binding
	Biological Process	Defense Response Inflammatory Response G-protein Coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Endothelial Cell Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Positive Regulation Of Cellular Extravasation Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Humoral Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger JAK-STAT Cascade Aging Regulation Of Cell Shape Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Bacterium Organ Morphogenesis Response To Gamma Radiation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Response To Activity Negative Regulation Of Angiogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Cellular Homeostasis Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Lipopolysaccharide-mediated Signaling Pathway Response To Progesterone Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin B3 Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Cellular Response To Drug Cellular Response To Macrophage Colony-stimulating Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Response To Amino Acid Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Maternal Process Involved In Female Pregnancy Maternal Process Involved In Parturition Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To ATP Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Calcium Ion Import Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) ATF4 activates genes GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide ligand-binding receptors Chemokine receptors bind chemokines PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs			Mimosine Danazol
Diseases
GWAS			Crohn's disease ( 22412388 21102463) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8	11 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 MMP1 MMP3 MMP8 VCAN
Entrez ID		2532	6347
HPRD ID		00192	01149
Ensembl ID		ENSG00000213088	ENSG00000108691
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	P13500
PDB IDs			1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Migration Chemokine-mediated Signaling Pathway Cell Motility Regulation Of Behavior Locomotion Immune Response Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Positive Regulation Of Locomotion Response To External Stimulus Granulocyte Chemotaxis Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Monocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Other Organism Response To Lipopolysaccharide Leukocyte Chemotaxis Response To Biotic Stimulus Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Regulation Of Lymphocyte Migration Cytokine-mediated Signaling Pathway Response To Bacterium Regulation Of Granulocyte Chemotaxis Response To Stress G-protein Coupled Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Leukocyte Migration Regulation Of Immune System Process Cellular Response To Interleukin-1 Positive Regulation Of Natural Killer Cell Chemotaxis Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Locomotion Inflammatory Response Chemotaxis G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Defense Response Extracellular Matrix Organization Extracellular Structure Organization Dendritic Cell Chemotaxis Response To Stress Cellular Metal Ion Homeostasis Positive Regulation Of Protein Oligomerization Cellular Cation Homeostasis Cellular Ion Homeostasis Neutrophil Activation Metal Ion Homeostasis Dendritic Cell Migration Response To External Stimulus Cellular Chemical Homeostasis Regulation Of Protein Oligomerization Ion Homeostasis Leukocyte Migration Cell Surface Receptor Signaling Pathway Immune Response Immune System Process Cellular Homeostasis Cellular Defense Response Cell Migration Chemical Homeostasis Receptor-mediated Endocytosis Cell Motility Leukocyte Chemotaxis Viral Process Response To Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?			balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit
Tagcloud (Difference) ?			balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit
Tagcloud (Intersection) ?