ACKR1 and CCL17

Number of citations of the paper that reports this interaction (PubMedID 13679391)
0

Data Source:
HPRD (in vivo)

		ACKR1	CCL17
Description		atypical chemokine receptor 1 (Duffy blood group)	C-C motif chemokine ligand 17
Image
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Chemokine Binding C-C Chemokine Binding Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Defense Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Peptide ligand-binding receptors	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)	Blood protein levels ( 30072576) Thymus and reactivation regulated chemokine levels ( 33227023)
Interacting Genes		9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B	9 interacting genes: ACKR1 CCL21 CCL25 CCL26 CCL28 CCL5 CCR4 CCR8 VCAM1
Entrez ID		2532	6361
HPRD ID		00192	03309
Ensembl ID		ENSG00000213088	ENSG00000102970
Uniprot IDs		Q16570 Q5Y7A1 Q5Y7A2	Q92583
PDB IDs		4NUU 4NUV 7P93 8A44 8JPS	1NR2 1NR4 5WK3 7S4N 7SCV 8FJ2 8SKK
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Inflammatory Response Leukocyte Chemotaxis Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response To Symbiont Defense Response To Other Organism Defense Response CCR Chemokine Receptor Binding Leukocyte Migration Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Response To Other Organism Immune System Process Response To External Biotic Stimulus G Protein-coupled Receptor Signaling Pathway Extracellular Region Regulation Of Leukocyte Migration Chemokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Leukocyte Chemotaxis Monocyte Chemotaxis Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Killing Of Cells Of Another Organism Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Signal Transduction Positive Regulation Of Chemotaxis Response To Fibroblast Growth Factor CCR2 Chemokine Receptor Binding Response To Stress Cell Killing Cellular Response To Interleukin-1 Regulation Of Granulocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Inflammatory Response Chemokine Receptor Binding Chemokine Activity Cytokine-mediated Signaling Pathway Granulocyte Chemotaxis Eosinophil Chemotaxis Eosinophil Migration Negative Regulation Of Leukocyte Tethering Or Rolling Cell Migration Granulocyte Migration CCR Chemokine Receptor Binding Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Negative Regulation Of Cellular Extravasation Antimicrobial Humoral Response Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cytokine Activity Regulation Of Leukocyte Tethering Or Rolling Leukocyte Migration Humoral Immune Response Immune System Process C-C Chemokine Binding Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell-matrix Adhesion Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Response To Stress Response To External Biotic Stimulus Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Adhesion
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