CCL3 and CCR4

Number of citations of the paper that reports this interaction (PMID 8573157)
7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CCL3	CCR4
Gene Name		chemokine (C-C motif) ligand 3	chemokine (C-C motif) receptor 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body
	Molecular Function	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding	Chemokine Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization Cell-cell Signaling Behavior Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Catalytic Activity Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Natural Killer Cell Chemotaxis	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Response To Antibiotic Positive Regulation Of Positive Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		9 interactors: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1	6 interactors: ADRBK1 ADRBK2 CCL17 CCL22 CCL3 CCL5
Entrez ID		6348	1233
HPRD ID		01656	05324
Ensembl ID		ENSG00000006075
Uniprot IDs		A0N0R1 P10147	A0N0Q1 P51679
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 3TN1
Enriched GO Terms of Interacting Partners?		Inflammatory Response Chemokine-mediated Signaling Pathway Defense Response Regulation Of Ossification Response To External Stimulus Negative Regulation Of Ossification Chemotaxis Response To Stress Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Immune Response Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Cellular Response To Organic Substance Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Bone Mineralization Cellular Homeostasis Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipopolysaccharide Tolerance Induction Response To Molecule Of Bacterial Origin Response To Organic Substance Positive Regulation Of Locomotion Cell Migration Chemical Homeostasis Cell Motility Cellular Response To Stimulus Dendritic Cell Chemotaxis Regulation Of Fat Cell Differentiation Response To Bacterium Negative Regulation Of Bone Mineralization Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biomineral Tissue Development Response To Cholesterol	Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Inflammatory Response Eosinophil Chemotaxis Eosinophil Migration Negative Regulation By Host Of Viral Transcription Immune Response Defense Response Monocyte Chemotaxis Chemotaxis Macrophage Chemotaxis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Viral Transcription Positive Chemotaxis Cell Migration Regulation Of Lymphocyte Migration Interaction With Symbiont Cell Motility Cell-cell Signaling Immune System Process Lipopolysaccharide-mediated Signaling Pathway Protein Kinase B Signaling Receptor Internalization Cellular Response To Interleukin-1 Granulocyte Chemotaxis Termination Of G-protein Coupled Receptor Signaling Pathway Locomotion Termination Of Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Signal Transduction Regulation Of Viral Transcription Protein Phosphorylation Negative Regulation Of Viral Process Positive Regulation Of Phospholipase Activity Receptor Metabolic Process Signaling Vesicle-mediated Transport Response To Interleukin-1 Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Leukocyte Migration Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Tumor Necrosis Factor Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration
Tagcloud ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	allergic ccr1 ccr3 ccr5 chemokine chemokines coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Difference) ?		backgroundmonocyte ccl4 ccl7 cd45 conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	allergic ccr1 ccr3 ccr5 chemokine coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate
Tagcloud (Intersection) ?		chemokines