CCL3 and CEBPB

Number of citations of the paper that reports this interaction (PubMedID 9885903)
0

Data Source:
HPRD (in vivo)

		CCL3	CEBPB
Description		C-C motif chemokine ligand 3	CCAAT enhancer binding protein beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix CHOP-C/EBP Complex RNA Polymerase II Transcription Regulator Complex C/EBP Complex
	Molecular Function	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Chromatin DNA Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Host-mediated Suppression Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Liver Development Embryonic Placenta Development Granuloma Formation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Acute-phase Response Inflammatory Response Immune Response Memory Positive Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-4 Production Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress T-helper 1 Cell Activation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Myeloid Cell Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Interleukin-1 Hepatocyte Proliferation Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling Regulation Of Odontoblast Differentiation Positive Regulation Of Sodium-dependent Phosphate Transport Regulation Of Dendritic Cell Differentiation
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) ATF4 activates genes in response to endoplasmic reticulum stress Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Transcriptional regulation of granulopoiesis Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Nuclear events stimulated by ALK signaling in cancer
Drugs		ROX-888	Quercetin
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971)	Bronchodilator response in asthma ( 25562107) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Meconium ileus in cystic fibrosis ( 30807572) Pancreas fat ( 34128465) Type 2 diabetes ( 30297969 30718926 32499647)
Interacting Genes		12 interacting genes: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SNCA SRGN TGFB1 UBQLN1 UBQLN2	58 interacting genes: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 DMAP1 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED20 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 NUP50 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIB1 TRIM28
Entrez ID		6348	1051
HPRD ID		01656	01801
Ensembl ID		ENSG00000277632	ENSG00000172216
Uniprot IDs		A0N0R1 P10147	P17676
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65 7F1Q 7F1T	1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43 6MG1 6MG2 6MG3 7L4V 7UPZ 8K8D
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Inflammatory Response Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemotaxis Calcium-mediated Signaling Locomotion Cytokine-mediated Signaling Pathway Response To Stress Regulation Of Calcium Ion Transport Immune Response Chemokine (C-C Motif) Ligand 5 Binding Immune System Process Negative Regulation Of Biomineral Tissue Development Defense Response Cell Migration Response To Cytokine Response To Peptide Regulation Of Metal Ion Transport Cell Motility External Side Of Plasma Membrane Negative Regulation Of Ossification G Protein-coupled Receptor Activity Positive Regulation Of Inflammatory Response Regulation Of Monoatomic Ion Transport Cellular Response To Cytokine Stimulus G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Transport Dendritic Cell Chemotaxis Tolerance Induction Positive Regulation Of ERAD Pathway Negative Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Regulation Of Sequestering Of Calcium Ion Leukocyte Chemotaxis Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Response To Cholesterol Regulation Of ERAD Pathway Regulation Of Calcium Ion Transmembrane Transport	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of MiRNA Transcription Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Regulation Of Cell Differentiation Regulation Of Developmental Process DNA-templated Transcription Positive Regulation Of Multicellular Organismal Process
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