CCL3 and CCR3

Number of citations of the paper that reports this interaction (PMID 7594543)
15

Data Source:
HPRD (in vitro)

		CCL3	CCR3
Gene Name		chemokine (C-C motif) ligand 3	chemokine (C-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Cytoplasm Cytosol	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization Cell-cell Signaling Behavior Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Catalytic Activity Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Natural Killer Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6348	1232
HPRD ID		01656	03167
Ensembl ID		ENSG00000006075	ENSG00000183625
Uniprot IDs		A0N0R1 P10147	P51677 Q8TDP4 Q8TDP5
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 3TN1
Enriched GO Terms of Interacting Partners?		Inflammatory Response Chemokine-mediated Signaling Pathway Defense Response Regulation Of Ossification Response To External Stimulus Negative Regulation Of Ossification Chemotaxis Response To Stress Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Immune Response Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Cellular Response To Organic Substance Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Bone Mineralization Cellular Homeostasis Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipopolysaccharide Tolerance Induction Response To Molecule Of Bacterial Origin Response To Organic Substance Positive Regulation Of Locomotion Cell Migration Chemical Homeostasis Cell Motility Cellular Response To Stimulus Dendritic Cell Chemotaxis Regulation Of Fat Cell Differentiation Response To Bacterium Negative Regulation Of Bone Mineralization Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biomineral Tissue Development Response To Cholesterol	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?