CCL3 and CCR3

Number of citations of the paper that reports this interaction (PubMedID 7594543)
0

Data Source:
HPRD (in vitro)

		CCL3	CCR3
Description		C-C motif chemokine ligand 3	C-C motif chemokine receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Host-mediated Suppression Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		ROX-888
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 33393726 23291587) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 25920553 20190752 22057235 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 27863252 29403010) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SNCA SRGN TGFB1 UBQLN1 UBQLN2	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6348	1232
HPRD ID		01656	03167
Ensembl ID		ENSG00000277632	ENSG00000183625
Uniprot IDs		A0N0R1 P10147	P51677 Q8TDP4 Q8TDP5
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65 7F1Q 7F1T	7X9Y
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Inflammatory Response Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemotaxis Calcium-mediated Signaling Locomotion Cytokine-mediated Signaling Pathway Response To Stress Regulation Of Calcium Ion Transport Immune Response Chemokine (C-C Motif) Ligand 5 Binding Immune System Process Negative Regulation Of Biomineral Tissue Development Defense Response Cell Migration Response To Cytokine Response To Peptide Regulation Of Metal Ion Transport Cell Motility External Side Of Plasma Membrane Negative Regulation Of Ossification G Protein-coupled Receptor Activity Positive Regulation Of Inflammatory Response Regulation Of Monoatomic Ion Transport Cellular Response To Cytokine Stimulus G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Transport Dendritic Cell Chemotaxis Tolerance Induction Positive Regulation Of ERAD Pathway Negative Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Regulation Of Sequestering Of Calcium Ion Leukocyte Chemotaxis Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Response To Cholesterol Regulation Of ERAD Pathway Regulation Of Calcium Ion Transmembrane Transport	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Granulocyte Chemotaxis Locomotion Defense Response To Symbiont Inflammatory Response Defense Response To Other Organism Granulocyte Migration Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Eosinophil Migration Leukocyte Migration Myeloid Leukocyte Migration Response To Other Organism Immune Response Cell Migration Response To External Biotic Stimulus Defense Response Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Extracellular Space Cell Surface Receptor Signaling Pathway Extracellular Region Response To Stress Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Cell Communication Regulation Of Leukocyte Migration Regulation Of Cell Shape Positive Regulation Of Leukocyte Migration Signal Transduction Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Calcium Ion Transport Intracellular Calcium Ion Homeostasis
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