SCT and SCTR

Number of citations of the paper that reports this interaction (PubMedID 9440501)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SCT	SCTR
Description		secretin	secretin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Digestive Hormone Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding
	Biological Process	Diet Induced Thermogenesis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Intracellular Water Homeostasis Hippocampus Development Pancreatic Juice Secretion Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity Embryonic Digestive Tract Development Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Somatostatin Secretion Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Gastrin-induced Gastric Acid Secretion	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Secretin human
Diseases
GWAS			Bipolar disorder ( 31043756) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		8 interacting genes: HGS HOXA1 MEIS2 MEP1A MEP1B SCTR USHBP1 VIPR1	9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1
Entrez ID		6343	6344
HPRD ID		08354	01628
Ensembl ID		ENSG00000070031	ENSG00000080293
Uniprot IDs		P09683	P47872 Q8IV17
PDB IDs		6WI9 6WZG 7D3S	6WI9 6WZG 7D3S
Enriched GO Terms of Interacting Partners?		Meprin A Complex G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Visual Behavior Semicircular Canal Formation Secretin Receptor Activity Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cardiac Muscle Myoblast Proliferation Epidermal Growth Factor Receptor Ligand Maturation Metalloendopeptidase Activity Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity ESCRT-0 Complex Metallopeptidase Activity Phagocytic Vesicle Lumen Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane
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