SCT and MEIS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCT	MEIS2
Description		secretin	Meis homeobox 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Digestive Hormone Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Diet Induced Thermogenesis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Intracellular Water Homeostasis Hippocampus Development Pancreatic Juice Secretion Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity Embryonic Digestive Tract Development Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Somatostatin Secretion Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Gastrin-induced Gastric Acid Secretion	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Regulation Of DNA-templated Transcription Brain Development Positive Regulation Of Cell Population Proliferation Visual Learning Response To Mechanical Stimulus Embryonic Pattern Specification Animal Organ Morphogenesis Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Postprandial triglyceride response ( 32603185) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		8 interacting genes: HGS HOXA1 MEIS2 MEP1A MEP1B SCTR USHBP1 VIPR1	50 interacting genes: ADRA2C ANTKMT ANXA1 APP ARNT2 BPIFA1 C1orf94 CARTPT CCDC196 CTAG1A CTAG1B DGCR6 DRD1 FAM136A FAM168A HOXA13 HOXA9 IGFBP6 ITGB3BP KRTAP10-8 KRTAP11-1 KRTAP13-1 KRTAP19-2 KRTAP19-6 KRTAP22-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 MCCD1 NDUFB7 NOTO NUP58 OIP5 OSGIN1 PBX1 POU2AF1 POU6F2 PTK6 RBPMS RUSC1 SCT SPMIP6 SQSTM1 TBX2 TIMM10B TLX1 TRIM25 TRIM42 VGLL1 ZNHIT3
Entrez ID		6343	4212
HPRD ID		08354	03443
Ensembl ID		ENSG00000070031	ENSG00000134138
Uniprot IDs		P09683	B3KPD8 B7Z6F6 O14770
PDB IDs		6WI9 6WZG 7D3S	3K2A 4XRM 5BNG 5EG0
Enriched GO Terms of Interacting Partners?		Meprin A Complex G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Visual Behavior Semicircular Canal Formation Secretin Receptor Activity Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cardiac Muscle Myoblast Proliferation Epidermal Growth Factor Receptor Ligand Maturation Metalloendopeptidase Activity Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity ESCRT-0 Complex Metallopeptidase Activity Phagocytic Vesicle Lumen Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Intermediate Filament Positive Regulation Of Long-term Synaptic Potentiation
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