ACOX1 and TYSND1

Number of citations of the paper that reports this interaction (PubMedID 22002062)
71

Data Source:
BioGRID (enzymatic study)

		ACOX1	TYSND1
Description		acyl-CoA oxidase 1	trypsin like peroxisomal matrix peptidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Peroxisome Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Acyl-CoA Oxidase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors PDZ Domain Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding FAD Binding Long-chain Fatty Acyl-CoA Oxidase Activity	Protease Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Spermatogenesis Fatty Acid Catabolic Process Peroxisome Fission Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Cholesterol Homeostasis Long-chain Fatty Acid Biosynthetic Process Hydrogen Peroxide Biosynthetic Process Lipid Homeostasis Very Long-chain Fatty Acid Beta-oxidation Fatty Acid Derivative Biosynthetic Process	Proteolysis Protein Processing Regulation Of Fatty Acid Beta-oxidation
Pathways		Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins TYSND1 cleaves peroxisomal proteins
Drugs		Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Body mass index ( 28552196) Diastolic blood pressure ( 27841878) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28135244) Urinary metabolite levels in chronic kidney disease ( 31959995) White matter hyperintensities ( 30002152) White matter hyperintensity burden ( 25663218)
Interacting Genes		4 interacting genes: OGT SCP2 SLC2A4 TYSND1	3 interacting genes: ACOX1 TH UBC
Entrez ID		51	219743
HPRD ID		02030	15593
Ensembl ID		ENSG00000161533	ENSG00000156521
Uniprot IDs		Q15067	Q2T9J0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Peroxisomal Matrix Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Peroxisome Positive Regulation Of Lipid Metabolic Process Lipid Hydroperoxide Transport Oleic Acid Binding Acetyl-CoA C-myristoyltransferase Activity Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Response To Insulin Protein Processing Protein O-acetylglucosaminyltransferase Activity Regulation Of Lipid Biosynthetic Process Long-chain Fatty Acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Positive Regulation Of Intracellular Lipid Transport Carbohydrate Homeostasis Glucose Homeostasis White Fat Cell Proliferation Progesterone Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Phosphatidylcholine Transfer Activity Inositol Trisphosphate Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Intracellular Cholesterol Transport Dehydroascorbic Acid Transport Response To Peptide Hormone Fat Cell Proliferation Protein Maturation Regulation Of Intracellular Lipid Transport Regulation Of Transcription By Glucose Regulation Of Small Molecule Metabolic Process Lipid Binding D-glucose Transmembrane Transporter Activity C21-steroid Hormone Biosynthetic Process Phosphatidylinositol Transfer Activity NSL Complex	Very Long-chain Fatty Acid Beta-oxidation Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Long-chain Fatty Acyl-CoA Oxidase Activity Acyl-CoA Oxidase Activity Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Hyaloid Vascular Plexus Regression Very Long-chain Fatty Acid Catabolic Process Norepinephrine Biosynthetic Process Reactive Oxygen Species Biosynthetic Process Alpha-linolenic Acid Metabolic Process Hydrogen Peroxide Biosynthetic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Synaptic Transmission, Dopaminergic Serotonin Metabolic Process Anatomical Structure Regression Dopamine Biosynthetic Process Norepinephrine Metabolic Process Embryonic Camera-type Eye Morphogenesis Tyrosine Metabolic Process Protein Tag Activity Catecholamine Biosynthetic Process Smooth Endoplasmic Reticulum Mating Behavior Melanosome Membrane Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Oxidoreductase Activity Fatty Acid Binding Prostanoid Metabolic Process Hydrogen Peroxide Metabolic Process Very Long-chain Fatty Acid Metabolic Process Prostaglandin Metabolic Process Amine Biosynthetic Process Eating Behavior Eye Photoreceptor Cell Development Biogenic Amine Biosynthetic Process Reproductive Behavior Embryonic Eye Morphogenesis Dopamine Metabolic Process Long-chain Fatty Acid Biosynthetic Process Aromatic Amino Acid Metabolic Process Photoreceptor Cell Development FAD Binding Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process
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