RBFOX1 and NUMBL

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RBFOX1	NUMBL
Gene Name		RNA binding protein, fox-1 homolog (C. elegans) 1	numb homolog (Drosophila)-like
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network	Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Protein C-terminus Binding	Protein Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of RNA Splicing RNA Transport Neuromuscular Process Controlling Balance	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 23396134 23474815)	Kawasaki disease ( 22446962)
Protein-Protein Interactions		33 interactors: ALG13 ATN1 ATXN1 ATXN2 BHLHE40 C1orf94 CELF3 CRX DAB1 DAZAP2 DMRTB1 DVL2 FAM168A GCA HNRNPF HSFX1 HSFY1 KIFAP3 LZTS2 MAGED1 NOC2L NUMBL PCBP4 PRR20A PRRC2A PSMF1 QKI RBFOX2 RBM24 RBPMS RHOXF2 SNRPN TNIP1	23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		54715	9253
HPRD ID		16091	04931
Ensembl ID		ENSG00000078328
Uniprot IDs		B7Z1U7 F5H0M1 Q59HD3 Q9NWB1	Q9Y6R0
PDB IDs		2ERR	3F0W
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Regulation Of Cellular Process RNA Splicing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Signal Transduction RNA Biosynthetic Process Regulation Of RNA Splicing Cellular Macromolecule Biosynthetic Process Negative Regulation Of Signaling Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Migration In Hindbrain Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Canonical Wnt Signaling Pathway Hindbrain Development Biosynthetic Process Circadian Rhythm Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression MRNA Processing Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Calcium-dependent Cell-cell Adhesion Positive Regulation Of Photoreceptor Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cerebellum Morphogenesis Regulation Of MRNA Stability Hindbrain Morphogenesis Regulation Of RNA Stability Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process	Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual litaf microdeletions novo omim overlapping pmm2 spanning tmem114 vertebral	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual litaf microdeletions novo omim overlapping pmm2 spanning tmem114 vertebral	ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?