MPPED2 and POMP

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MPPED2	POMP
Name		metallophosphoesterase domain containing 2	proteasome maturation protein
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding Hydrolase Activity GMP Binding Manganese Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	None	Proteasome Assembly
Pathways		None	Proteasome assembly Proteasome assembly
Diseases		None	Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
GWAS		Adventurousness ( 30643258 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Asthma ( 27611488 ) Automobile speeding propensity ( 30643258 ) Blood urea nitrogen levels ( 29403010 ) Chronic kidney disease ( 22479191 26831199 ) Chronotype ( 30696823 ) Creatinine levels ( 29403010 ) Dental caries ( 21940522 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Falling risk ( 32999390 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder ( 27479909 ) Medication use (diuretics) ( 31015401 ) Migraine ( 27322543 ) Morning person ( 30696823 ) Pit-and-Fissure caries ( 24556642 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Renal function-related traits (eGRFcrea) ( 22797727 ) Renal function-related traits (sCR) ( 22797727 ) Serum uric acid levels ( 30993211 29403010 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure ( 30578418 ) Triglyceride levels ( 32203549 ) Urate levels ( 31578528 )	Breast cancer (menopausal hormone therapy interaction) ( 24080446 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 )
Interacting Genes		14 interacting genes: BEX4 CAGE1 FAM72A HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 POMP RIBC1 RUNX1 RXRG TRIP13 VAC14	24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL
Entrez ID		744	51371
HPRD ID		02947	12613
Ensembl ID		ENSG00000066382	ENSG00000132963
Uniprot IDs		Q15777	Q9Y244
PDB IDs		Not available	8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY
GO Terms Enriched among Interactors		None	Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle