MPPED2 and BEX4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MPPED2	BEX4
Name		metallophosphoesterase domain containing 2	brain expressed X-linked 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule
	Molecular Function	Nucleotide Binding Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding Hydrolase Activity GMP Binding Manganese Ion Binding Metal Ion Binding	Protein Binding Histone Deacetylase Binding Alpha-tubulin Binding Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	None	Chromosome Segregation Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Negative Regulation Of Tubulin Deacetylation
GWAS		Adventurousness ( 30643258 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Asthma ( 27611488 ) Automobile speeding propensity ( 30643258 ) Blood urea nitrogen levels ( 29403010 ) Chronic kidney disease ( 22479191 26831199 ) Chronotype ( 30696823 ) Creatinine levels ( 29403010 ) Dental caries ( 21940522 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Falling risk ( 32999390 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder ( 27479909 ) Medication use (diuretics) ( 31015401 ) Migraine ( 27322543 ) Morning person ( 30696823 ) Pit-and-Fissure caries ( 24556642 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Renal function-related traits (eGRFcrea) ( 22797727 ) Renal function-related traits (sCR) ( 22797727 ) Serum uric acid levels ( 30993211 29403010 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure ( 30578418 ) Triglyceride levels ( 32203549 ) Urate levels ( 31578528 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: BEX4 CAGE1 FAM72A HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 POMP RIBC1 RUNX1 RXRG TRIP13 VAC14	5 interacting genes: FMR1 HSPB2 MPPED2 PKNOX1 VHL
Entrez ID		744	56271
HPRD ID		02947	09823
Ensembl ID		ENSG00000066382	ENSG00000102409
Uniprot IDs		Q15777	Q9NWD9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	GMP Binding Dendritic Filopodium Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Histone H3 Reader Activity Positive Regulation Of Intracellular Transport Of Viral Material U12 SnRNA Binding