RRM1 and KAT5

Number of citations of the paper that reports this interaction (PMID 20159953)
25

Data Source:
BioGRID (pull down)

		RRM1	KAT5
Gene Name		ribonucleotide reductase M1	K(lysine) acetyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		8 interactors: BMI1 KAT5 LRIF1 PPP1CC RNF2 RRM2 RRM2B YWHAG	136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513
Entrez ID		6240	10524
HPRD ID		01588	03245
Ensembl ID		ENSG00000167325	ENSG00000172977
Uniprot IDs		E9PD78 P23921	Q92993
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF	2EKO 2OU2
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Histone Ubiquitination Mitotic Cell Cycle Deoxyribonucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Histone Modification DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Acetylation Cell Cycle Internal Peptidyl-lysine Acetylation Histone H2A-K119 Monoubiquitination Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Chromatin Modification Protein Acetylation Positive Regulation Of Immature T Cell Proliferation In Thymus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Immature T Cell Proliferation Cellular Aromatic Compound Metabolic Process Chromatin Organization Biosynthetic Process Regulation Of Gene Expression Organelle Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Histone H2A Monoubiquitination Chromosome Organization Regulation Of Cellular Process Mitochondrial DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Nucleotide Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction Resulting In Transcription	Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?