RRM1 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 11517226)
0

Data Source:
HPRD (in vivo)

		RRM1	RRM2B
Description		ribonucleotide reductase catalytic subunit M1	ribonucleotide reductase regulatory TP53 inducible subunit M2B
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex Centriolar Satellite Ciliary Basal Body Cell Projection Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Oxidoreductase Activity Purine Nucleotide Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Pyrimidine Nucleobase Metabolic Process Mitochondrial DNA Replication DNA Repair Male Gonad Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye Positive Regulation Of G0 To G1 Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA Synthesis Involved In DNA Repair Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair DNA Damage Response Response To Oxidative Stress Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Amine Positive Regulation Of G0 To G1 Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Interconversion of nucleotide di- and triphosphates	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine	Cladribine
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)	Blood protein levels ( 30072576) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: BMI1 CDC42 CEBPA LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	9 interacting genes: CDKN1A CSNK2A1 MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		6240	50484
HPRD ID		01588	05276
Ensembl ID		ENSG00000167325	ENSG00000048392
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	Q7LG56
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?		RING-like Zinc Finger Domain Binding Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Complex Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Regulation Of Store-operated Calcium Entry PRC1 Complex	Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Cell Cycle Process Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Actinomycin D Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Response To Actinomycin D DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Gamma Radiation Regulation Of Mitotic Cell Cycle Cellular Response To UV-C Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Metabolic Process Stress-induced Premature Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Antibiotic Protein-containing Complex Assembly Protein Tetramerization Signal Transduction By P53 Class Mediator DNA Damage Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Mitophagy Cellular Response To Light Stimulus Protein-containing Complex Organization DNA Damage Response Response To UV-C Replicative Senescence Positive Regulation Of Cell Cycle Phase Transition 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Cytosol Regulation Of Signal Transduction By P53 Class Mediator Cellular Component Assembly Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
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