RRM1 and RRM2

Number of citations of the paper that reports this interaction (PMID 11781084)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RRM1	RRM2
Gene Name		ribonucleotide reductase M1	ribonucleotide reductase M2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	E2F mediated regulation of DNA replication G1/S Transition G1/S-Specific Transcription Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: BMI1 KAT5 LRIF1 PPP1CC RNF2 RRM2 RRM2B YWHAG	7 interactors: CDH1 CDK1 DNM1L KAT5 RRM1 RRM2B TP53
Entrez ID		6240	6241
HPRD ID		01588	01587
Ensembl ID		ENSG00000167325	ENSG00000171848
Uniprot IDs		E9PD78 P23921	P31350
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF	2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Histone Ubiquitination Mitotic Cell Cycle Deoxyribonucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Histone Modification DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Acetylation Cell Cycle Internal Peptidyl-lysine Acetylation Histone H2A-K119 Monoubiquitination Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Chromatin Modification Protein Acetylation Positive Regulation Of Immature T Cell Proliferation In Thymus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Immature T Cell Proliferation Cellular Aromatic Compound Metabolic Process Chromatin Organization Biosynthetic Process Regulation Of Gene Expression Organelle Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Histone H2A Monoubiquitination Chromosome Organization Regulation Of Cellular Process Mitochondrial DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Nucleotide Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction Resulting In Transcription	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Protein Tetramerization Protein Complex Assembly Protein Oligomerization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion DNA Damage Checkpoint Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial DNA Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Toxic Substance Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Oligomerization Mitochondrial Genome Maintenance Necroptotic Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Cell Cycle Checkpoint Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Organelle Organization Regulation Of Protein Localization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Proteasomal Protein Catabolic Process DNA Replication Membrane Organization Cellular Component Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Programmed Necrotic Cell Death Necrotic Cell Death Apoptotic Process Positive Regulation Of Protein Transport Deoxyribonucleotide Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes
Tagcloud (Difference) ?		11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph	antagonizing compass disparate dispensing diverge employs euchromatin fission h3k4me hulc intricacies intriguingly mat mating mst1 orthologs pericentromeric pombe relying repressing retrotransposons schizosaccharomyces set1 set1c subtelomeres subtelomeric tf2 tf2s utilizes
Tagcloud (Intersection) ?