RRAS and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 15031288)
0

Data Source:
HPRD (two hybrid, in vitro)

		RRAS	RASIP1
Description		RAS related	Ras interacting protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Cytoplasm Golgi Apparatus Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Leukocyte Differentiation Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Migration Schwann Cell Migration Positive Regulation Of Angiogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Schwann Cell Migration Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 21102463 28067908) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252 32888494) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		17 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1 TRIM55 TRIM63	9 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2 UBC
Entrez ID		6237	54922
HPRD ID		01299	15214
Ensembl ID		ENSG00000126458	ENSG00000105538
Uniprot IDs		P10301	Q5U651 Q7L251 Q8IUR2
PDB IDs		2FN4 7S0Z	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?		Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Signal Transduction Lymphocyte Homeostasis Regulation Of Intracellular Signal Transduction Leukocyte Homeostasis Lymphocyte Activation Pore Complex Regulation Of Phosphorus Metabolic Process Regulation Of Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Glycolytic Process Schwann Cell Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation MAP Kinase Kinase Kinase Activity Negative Regulation Of ATP Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Activation B Cell Homeostasis Cell Activation Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Catabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Protein Modification Process Cytoplasm T Cell Homeostasis Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Intracellular Signal Transduction Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Positive Regulation Of B Cell Proliferation Homeostasis Of Number Of Cells Ribosome Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Positive Regulation Of Protein-containing Complex Assembly RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity	GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding G Protein Activity Ras Protein Signal Transduction Schwann Cell Migration Intracellular Signaling Cassette Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Regulation Of Vasculogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Hydrolase Activity Regulation Of Glial Cell Migration Regulation Of Cell Migration Nucleotide Binding Regulation Of Cell Motility Intracellular Signal Transduction Regulation Of Protein Localization To Synapse Regulation Of Locomotion Regulation Of Receptor Localization To Synapse Glial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Plasma Membrane Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Projection Organization GTPase Complex Response To Antineoplastic Agent Phospholipase C Activator Activity Negative Regulation Of Schwann Cell Migration Positive Regulation Of Schwann Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of JNK Cascade Positive Regulation Of Microvillus Assembly Regulation Of Protein Localization To Cell Periphery Oncogene-induced Cell Senescence Golgi Membrane Regulation Of Protein Localization To Membrane Golgi Apparatus Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Guanyl-nucleotide Exchange Factor Complex Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Glial Cell Migration LIM Domain Binding
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