RRAS and NAV2

Number of citations of the paper that reports this interaction (PMID 15031288)
17

Data Source:
HPRD (in vitro)

		RRAS	NAV2
Gene Name		related RAS viral (r-ras) oncogene homolog	neuron navigator 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome	Interstitial Matrix Nucleoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding	Helicase Activity ATP Binding Heparin Binding
	Biological Process	Leukocyte Differentiation Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Metabolic Process Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development
Pathways		Axon guidance Semaphorin interactions Activation of NMDA receptor upon glutamate binding and postsynaptic events SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ACY3 ARAF BCL2 EEF1A1 EPHB2 MLLT4 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1	10 interactors: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 RBM15 RBM15B RRAS
Entrez ID		6237	89797
HPRD ID		01299	07385
Ensembl ID		ENSG00000126458	ENSG00000166833
Uniprot IDs		P10301	A7E2D6 Q8IVL1
PDB IDs		2FN4	2YRN
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Signal Transduction Regulation Of Catalytic Activity Neuron Projection Morphogenesis Optic Nerve Development Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Small GTPase Mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Autophagy Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Neuron Development Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Cell Death Neurotrophin Signaling Pathway Death Cell Morphogenesis Regulation Of Protein Phosphorylation	Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Histone H3 Acetylation Histone H4 Acetylation Peptidyl-amino Acid Modification Histone Modification Chromosome Organization TRNA Wobble Adenosine To Inosine Editing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chromatin Modification Cell Cycle Arrest Positive Regulation Of Cell Death Regulation Of Growth Negative Regulation Of Odontogenesis Negative Regulation Of Cell Proliferation Positive Regulation Of Transcription Of Notch Receptor Target Immune System Development Regulation Of Myeloid Cell Differentiation Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Ossification Nucleobase-containing Compound Metabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cellular Response To DNA Damage Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Growth Histone H4-K12 Acetylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization DNA Replication Positive Regulation Of Pseudopodium Assembly DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Histone H4-K5 Acetylation Histone H4-K8 Acetylation Negative Regulation Of Androgen Receptor Signaling Pathway
Tagcloud ?		10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision exome favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert	amplifications analysing apc arid1a considerably copy epsilon excluding exome fam123b hypermethylation hypermutated igf2 integrative messenger microrna microsatellite mismatch mlh1 pik3ca pole quarter quarters rectum smad4 sox9 targetable tcf7l1 translocations
Tagcloud (Difference) ?		10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert	amplifications analysing apc arid1a considerably copy epsilon excluding fam123b hypermethylation hypermutated igf2 integrative messenger microrna microsatellite mismatch mlh1 pik3ca pole quarter quarters rectum smad4 sox9 targetable tcf7l1 translocations
Tagcloud (Intersection) ?		exome