RRAS and NAV2

Number of citations of the paper that reports this interaction (PubMedID 15031288)
0

Data Source:
HPRD (in vitro)

		RRAS	NAV2
Description		RAS related	neuron navigator 2
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Interstitial Matrix Nucleus Nucleoplasm Extracellular Matrix
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Nucleotide Binding Helicase Activity Protein Binding ATP Binding Heparin Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Leukocyte Differentiation Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Migration Schwann Cell Migration Positive Regulation Of Angiogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Schwann Cell Migration Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Nervous System Development Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development Cerebellar Cortex Development Neurogenesis
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Adverse response to drug ( 30420678) Atrial fibrillation ( 29892015 30061737) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) Brain morphology (MOSTest) ( 32665545) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General cognitive ability ( 29844566) Hepatitis ( 25705159) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lateral thalamic nuclei volume ( 34006833) Low susceptibility to hepatitis C infection ( 31206233) Macular thickness ( 30535121) Monobrow ( 27182965) Obesity-related traits ( 23251661) PR interval ( 32439900 30046033) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Smoking initiation (ever regular vs never regular) ( 30679032) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Waist circumference ( 28552196)
Interacting Genes		17 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1 TRIM55 TRIM63	12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS
Entrez ID		6237	89797
HPRD ID		01299	07385
Ensembl ID		ENSG00000126458	ENSG00000166833
Uniprot IDs		P10301	A7E2D6 Q8IVL1
PDB IDs		2FN4 7S0Z	2YRN
Enriched GO Terms of Interacting Partners?		Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Signal Transduction Lymphocyte Homeostasis Regulation Of Intracellular Signal Transduction Leukocyte Homeostasis Lymphocyte Activation Pore Complex Regulation Of Phosphorus Metabolic Process Regulation Of Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Glycolytic Process Schwann Cell Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation MAP Kinase Kinase Kinase Activity Negative Regulation Of ATP Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Activation B Cell Homeostasis Cell Activation Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Catabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Protein Modification Process Cytoplasm T Cell Homeostasis Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Intracellular Signal Transduction Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Positive Regulation Of B Cell Proliferation Homeostasis Of Number Of Cells Ribosome Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Positive Regulation Of Protein-containing Complex Assembly RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity	DNA Replication-dependent Chromatin Disassembly Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Histone H3K4me3 Reader Activity Histone Acetyltransferase Complex Chromatin Organization RNA Modification Nucleoplasm Protein Acetylation Fibroblast Proliferation TRNA Wobble Adenosine To Inosine Editing TRNA-specific Adenosine-34 Deaminase Activity Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process RNA Methylation Regulation Of DNA Biosynthetic Process RNA Metabolic Process
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