RRAS and ACY3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RRAS	ACY3
Description		RAS related	aminoacylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding	Aminoacylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding
	Biological Process	Leukocyte Differentiation Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Migration Schwann Cell Migration Positive Regulation Of Angiogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Schwann Cell Migration Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration	Aflatoxin activation and detoxification
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		17 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1 TRIM55 TRIM63	21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS
Entrez ID		6237	91703
HPRD ID		01299	12422
Ensembl ID		ENSG00000126458	ENSG00000132744
Uniprot IDs		P10301	E9PRA7 Q96HD9
PDB IDs		2FN4 7S0Z
Enriched GO Terms of Interacting Partners?		Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Signal Transduction Lymphocyte Homeostasis Regulation Of Intracellular Signal Transduction Leukocyte Homeostasis Lymphocyte Activation Pore Complex Regulation Of Phosphorus Metabolic Process Regulation Of Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Glycolytic Process Schwann Cell Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation MAP Kinase Kinase Kinase Activity Negative Regulation Of ATP Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Activation B Cell Homeostasis Cell Activation Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Catabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Protein Modification Process Cytoplasm T Cell Homeostasis Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Intracellular Signal Transduction Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Positive Regulation Of B Cell Proliferation Homeostasis Of Number Of Cells Ribosome Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Positive Regulation Of Protein-containing Complex Assembly RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity	Intermediate Filament
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