RPS12 and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 29721183)
101

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RPS12	HMGB1
Description		ribosomal protein S12	high mobility group box 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Ribosome Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Ribonucleoprotein Complex	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cell Surface Membrane Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Lipid Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity Receptor Ligand Activity RAGE Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Cytoplasmic Translation Translation Ribosomal Small Subunit Biogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Maintenance Of Translational Fidelity	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Activation Of Innate Immune Response Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Myeloid Progenitor Cell Differentiation Immune System Process Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell Glycogen Catabolic Process DNA Metabolic Process DNA Topological Change DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Chromatin Organization Chromatin Remodeling Transcription By RNA Polymerase II Autophagy Chemotaxis Inflammatory Response Immune Response DNA Damage Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Myeloid Cell Differentiation Lung Development Neuron Projection Development Heterochromatin Formation Regulation Of Restriction Endodeoxyribonuclease Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Viral Entry Into Host Cell Cell Development Regulation Of Viral Process Positive Chemotaxis Regulation Of DNA Metabolic Process Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Sprouting Angiogenesis Regulation Of Hemopoiesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1-dependent IKK and NF-kappa-B activation MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Chloroquine Ethyl pyruvate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Heel bone mineral density ( 30598549) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 2 diabetes nephropathy ( 21150874)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: APP HMGB1 IKBKG SNCA	132 interacting genes: ACBD3 AGER AGTRAP AKIP1 AR ATF7IP ATOH1 C1QA C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPA CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DAG1 DLAT DNAAF2 DNM2 DNMT1 DUX4 DYNC2I1 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDAC1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MALAT1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 STUB1 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM2 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 USP12 WNK4 YY1 ZFP36 ZNF24 ZNF428
Entrez ID		6206	3146
HPRD ID		04714	01228
Ensembl ID		ENSG00000112306	ENSG00000189403
Uniprot IDs		P25398	B7Z965 P09429 Q5T7C4
PDB IDs		4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO 8I9M
Enriched GO Terms of Interacting Partners?		Macrophage Activation Positive Regulation Of Catabolic Process Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy RAGE Receptor Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Neurotransmitter Uptake Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Positive Regulation Of Monocyte Chemotaxis Cellular Response To Copper Ion Amyloid Fibril Formation Microglial Cell Activation Response To Copper Ion Chemoattractant Activity Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Regulation Of Endocytosis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Small Molecule Metabolic Process Response To External Biotic Stimulus Positive Chemotaxis Regulation Of Autophagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Neuronal Synaptic Plasticity Regulation Of Immune System Process Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Response To Interleukin-1 Adult Locomotory Behavior Positive Regulation Of Programmed Cell Death Response To Peptide Response To Cytokine Regulation Of Vesicle-mediated Transport Leukocyte Activation Immune System Process Amyloid-beta Complex Innate Immune Response	Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regionalization Anterior/posterior Pattern Specification Transcription Cis-regulatory Region Binding Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Pattern Specification Process Positive Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis
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