RPS12

Description		ribosomal protein S12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Ribosome Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Cytoplasmic Translation Translation Ribosomal Small Subunit Biogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Maintenance Of Translational Fidelity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Heel bone mineral density ( 30598549) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		4 interacting genes: APP HMGB1 IKBKG SNCA
Entrez ID		6206
HPRD ID		04714
Ensembl ID		ENSG00000112306
Uniprot IDs		P25398
PDB IDs		4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Macrophage Activation Positive Regulation Of Catabolic Process Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy RAGE Receptor Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Neurotransmitter Uptake Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Positive Regulation Of Monocyte Chemotaxis Cellular Response To Copper Ion Amyloid Fibril Formation Microglial Cell Activation Response To Copper Ion Chemoattractant Activity Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Regulation Of Endocytosis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Small Molecule Metabolic Process Response To External Biotic Stimulus Positive Chemotaxis Regulation Of Autophagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Neuronal Synaptic Plasticity Regulation Of Immune System Process Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Response To Interleukin-1 Adult Locomotory Behavior Positive Regulation Of Programmed Cell Death Response To Peptide Response To Cytokine Regulation Of Vesicle-mediated Transport Leukocyte Activation Immune System Process Amyloid-beta Complex Innate Immune Response
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