SOD2 and CYP4F12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SOD2	CYP4F12
Description		superoxide dismutase 2	cytochrome P450 family 4 subfamily F member 12
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Superoxide Dismutase Activity Protein Binding Oxidoreductase Activity Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity
	Biological Process	Response To Reactive Oxygen Species Response To Superoxide Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Superoxide Metabolic Process Response To Oxidative Stress Mitochondrion Organization Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Response To Nutrient Levels Intracellular Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Cellular Response To Oxidative Stress Response To Isolation Stress Response To Immobilization Stress Vasodilation Response To Hydrogen Peroxide Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Response To Hyperoxia Multicellular Organismal-level Iron Ion Homeostasis Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Sodium Ion Homeostasis
Pathways		Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)	Fatty acids Eicosanoids
Drugs		Benzylsulfonic acid 3-Fluoro-L-tyrosine Benzoyl peroxide
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)	Glioma ( 34319593) LDL cholesterol levels ( 32203549)
Interacting Genes		9 interacting genes: APP CEP70 CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A	5 interacting genes: CFTR HSPA6 MEOX2 SOD2 TIMMDC1
Entrez ID		6648	66002
HPRD ID		00938	07102
Ensembl ID		ENSG00000291237	ENSG00000186204
Uniprot IDs		A0A384NL29 G5E9P6 P04179 Q96AM7	Q9HCS2
PDB IDs		1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9 7KKS 7KKU 7KKW 7KLB 8SKS 8VHW 8VHY 8VJ0 8VJ4 8VJ5 8VJ8 9BVY 9BW2 9BWM 9BWQ 9BWR
Enriched GO Terms of Interacting Partners?			Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Organic Hydroxy Compound Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Somite Specification Response To Magnetism Regulation Of Membrane Hyperpolarization Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Detection Of Oxygen Negative Regulation Of Membrane Hyperpolarization Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Response To Silicon Dioxide Response To L-ascorbic Acid Ethanolamine Transport Ethanolamine Transmembrane Transporter Activity Positive Regulation Of Tooth Mineralization Cellular Heat Acclimation Response To Superoxide Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Oxygen Radical Choline Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Choline Transport Response To Alcohol ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Intracellular Oxygen Homeostasis Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Response To Selenium Ion Amine Transport Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Response To Manganese Ion
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