RPA3 and RPA2

Number of citations of the paper that reports this interaction (PubMedID 9461578)
0

Data Source:
HPRD (in vitro, in vivo)

		RPA3	RPA2
Description		replication protein A3	replication protein A2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Estimated glomerular filtration rate ( 29779033) Insulin-like growth factors ( 21216879) Interstitial lung diseases in rheumatoid arthritis ( 32737115) Intraocular pressure ( 30591961) Serum creatinine levels ( 29779033) Urate levels in obese individuals ( 25811787)	HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ATRIP ERCC1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4 WAS	69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14
Entrez ID		6119	6118
HPRD ID		01567	01566
Ensembl ID		ENSG00000106399	ENSG00000117748
Uniprot IDs		A4D105 P35244	B4DUL2 P15927
PDB IDs		1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF 8RK2 9MJ5	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5
Enriched GO Terms of Interacting Partners?		Site Of Double-strand Break Double-strand Break Repair DNA Repair DNA Metabolic Process Single-stranded DNA Binding DNA Recombination DNA Damage Response DNA Replication Factor A Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Telomere Maintenance Regulation Of DNA Damage Checkpoint Response To Stress PML Body Nuclear Chromosome Regulation Of Cell Cycle Telomere Organization Nucleobase-containing Compound Metabolic Process DNA Replication Regulation Of Double-strand Break Repair Interstrand Cross-link Repair Damaged DNA Binding Regulation Of DNA Repair G-rich Strand Telomeric DNA Binding Nucleus Regulation Of Double-strand Break Repair Via Homologous Recombination Intracellular Signal Transduction Telomere Maintenance Via Recombination Lateral Element Mitotic G1 DNA Damage Checkpoint Signaling Chromosome Organization Mitotic G1/S Transition Checkpoint Signaling Single-stranded DNA Helicase Activity Nucleoplasm Mitotic Recombination Regulation Of DNA Recombination Response To Ionizing Radiation	DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process
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