RPA3 and MCM2

Number of citations of the paper that reports this interaction (PMID 12614612)
16

Data Source:
HPRD (two hybrid)

		RPA3	MCM2
Gene Name		replication protein A3, 14kDa	minichromosome maintenance complex component 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA Replication Factor A Complex	Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm Microtubule Cytoskeleton MCM Complex
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Protein Binding ATP Binding Histone Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cell Proliferation Regulation Of Cellular Response To Heat	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Nucleosome Assembly Cell Cycle Cellular Response To Interleukin-4
Pathways		HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS		Insulin-like growth factors ( 21216879)
Protein-Protein Interactions		7 interactors: CDC5L MCM2 PRPF19 RAD51 RPA1 RPA2 RPA4	47 interactors: AKAP8 APP ATM ATR CCNB2 CCNC CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL GNB5 GTF2B GTF2H1 HIST3H3 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHC2 PLK1 RAD52 RPA1 RPA2 RPA3 RPS4X TBP TCEA2 TERF1 TERF2IP
Entrez ID		6119	4171
HPRD ID		01567	00303
Ensembl ID			ENSG00000073111
Uniprot IDs		A4D105 P35244	P49736
PDB IDs		1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		DNA-dependent DNA Replication Cellular Response To DNA Damage Stimulus DNA Recombinase Assembly Cell Cycle Process DNA Metabolic Process DNA Repair Cell Cycle DNA Replication Cellular Response To Stress Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication Mitotic Recombination DNA Damage Checkpoint DNA Strand Elongation G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Cellular Macromolecular Complex Assembly Cell Cycle Checkpoint DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Nucleotide-excision Repair DNA Unwinding Involved In DNA Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Regulation Of Double-strand Break Repair DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Response To Heat Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Component Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Mitotic Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle DNA-dependent DNA Replication DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Biosynthetic Process Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Metabolic Process DNA Recombinase Assembly Telomere Maintenance Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Heat Positive Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Division Cell Cycle Checkpoint Double-strand Break Repair Organelle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle
Tagcloud ?		analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory	1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed
Tagcloud (Difference) ?		analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory	1alpha 1beta bcl2 carcinogenic ccr2 cervices e2 epithelia hek293 hpv16 ikappabalpha inflammation intact integration isomerase mediators peptidyl pin1 potentiated prolyl rela sdf ser727 squamous stat3 stromal supports survivin transformed
Tagcloud (Intersection) ?