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CFB
Description
complement factor B
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Extracellular Exosome
Blood Microparticle
Symbiont Cell Surface
Molecular Function
Complement Binding
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Biological Process
Activation Of Membrane Attack Complex
Pre-B Cell Differentiation
Immune System Process
Proteolysis
Complement Activation
Complement Activation, Alternative Pathway
Response To Bacterium
Killing Of Cells Of Another Organism
Innate Immune Response
Protein Maturation
Pathways
Alternative complement activation
Activation of C3 and C5
Regulation of Complement cascade
Drugs
Zinc
4-guanidinobenzoic acid
Diisopropylphosphono Group
MLN2222
Zinc acetate
Diseases
Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS
A body shape index (
34021172
)
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385826
23577725
23455636
20385819
22694956
21665990
)
Age-related macular degeneration (choroidal neovascularisation) (
22705344
)
Age-related macular degeneration (extreme sampling) (
23577725
)
Age-related macular degeneration (geographic atrophy) (
22705344
)
Asthma (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Chronic hepatitis B infection (
25802187
)
Coronary artery disease (
29212778
)
Disease progression in age-related macular degeneration (
29346644
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Height (
28552196
)
Hematology traits (
23263863
)
Inflammatory bowel disease (
28067908
)
Neutrophil percentage of white cells (
32888494
)
Prostate cancer (
23535732
)
Rosacea symptom severity (
29771307
)
Type 1 diabetes and autoimmune thyroid diseases (
25936594
)
Ulcerative colitis (
28067908
24837172
)
Novel Interacting Genes
1 novel interacting genes:
NOMO1
Interacting Genes
6 interacting genes:
C3
CFP
HSP90AA1
LAMC3
LAMTOR5
RPA2
Entrez ID
629
HPRD ID
00718
Ensembl ID
ENSG00000243649
Uniprot IDs
A0A1U9X7H8
P00751
PDB IDs
1DLE
1Q0P
1RRK
1RS0
1RTK
2OK5
2WIN
2XWB
2XWJ
3HRZ
3HS0
6QSW
6QSX
6RAV
6RUR
6RUV
6T8U
6T8V
6T8W
7JTN
7JTQ
7NOZ
8ENU
8EOK
8UIN
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Complement Activation
Complement Activation, Alternative Pathway
Regulation Of Complement Activation
Positive Regulation Of Humoral Immune Response
Regulation Of Humoral Immune Response
Positive Regulation Of Cytokine Production
Positive Regulation Of Phagocytosis
Positive Regulation Of Activation Of Membrane Attack Complex
Response To Other Organism
Complement Activation
C5L2 Anaphylatoxin Chemotactic Receptor Binding
Regulation Of Phagocytosis
Positive Regulation Of Defense Response
Activation Of Immune Response
Telomere Maintenance
Protein Phosphatase Binding
CTP Binding
Regulation Of Cell Size
DATP Binding
Neurofibrillary Tangle Assembly
UTP Binding
Positive Regulation Of Protein Localization To Nucleus
Sulfonylurea Receptor Binding
Positive Regulation Of Complement Activation, Alternative Pathway
Cytoplasmic Side Of Golgi Membrane
Response To External Biotic Stimulus
Secretory Granule Lumen
Complement-dependent Cytotoxicity
Classical-complement-pathway C3/C5 Convertase Complex
Vertebrate Eye-specific Patterning
Rho GDP-dissociation Inhibitor Binding
Telomere Organization
Oviduct Epithelium Development
Positive Regulation Of Type IIa Hypersensitivity
Complement-mediated Synapse Pruning
Protein Localization To Organelle
Negative Regulation Of Nodal Signaling Pathway
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Immune Response
Positive Regulation Of Endocytosis
Sperm Mitochondrial Sheath
Regulation Of Complement Activation, Alternative Pathway
Ragulator Complex
Telomerase Holoenzyme Complex Assembly
Regulation Of Cytokine Production
Positive Regulation Of Hypersensitivity
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Protein-containing Complex
Positive Regulation Of Apoptotic Cell Clearance
Chaperone-mediated Autophagy
Tagcloud
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