CFB and LAMC3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CFB	LAMC3
Gene Name		complement factor B	laminin, gamma 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Membrane
	Molecular Function	Complement Binding Serine-type Endopeptidase Activity	Structural Molecule Activity
	Biological Process	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response	Cell Morphogenesis Involved In Differentiation Cell Adhesion Visual Perception Astrocyte Development Extracellular Matrix Organization Retina Development In Camera-type Eye
Pathways		Alternative complement activation Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System	Laminin interactions Non-integrin membrane-ECM interactions
Drugs		4-Guanidinobenzoic Acid Diisopropylphosphono Group
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Hematology traits ( 23263863) Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: C3 CFP LAMC3 RPA2	20 interactors: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		629	10319
HPRD ID		00718	05069
Ensembl ID		ENSG00000243649	ENSG00000050555
Uniprot IDs		P00751	Q8N2D6 Q9Y6N6
PDB IDs		1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex DNA Recombinase Assembly Regulation Of Inflammatory Response Positive Regulation Of Hypersensitivity Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Protein Processing Regulation Of Apoptotic Cell Clearance Protein O-linked Fucosylation Regulation Of DNA Damage Checkpoint Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Humoral Immune Response Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Astrocyte Development Nuclear DNA Replication Telomere Maintenance Via Recombination Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Double-strand Break Repair Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Fucosylation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Cell Cycle Checkpoint Innate Immune Response Astrocyte Differentiation Transcription-coupled Nucleotide-excision Repair Regulation Of Immune Response Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis	Acute-phase Response Acute Inflammatory Response Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Protein Processing Defense Response Regulation Of Immune Response Regulation Of Macrophage Derived Foam Cell Differentiation Response To Stress Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Lipid Storage Regulation Of Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Chromosome Organization Regulation Of High-density Lipoprotein Particle Assembly Telomere Formation Via Telomerase Negative Regulation Of Proteolysis Regulation Of Immune System Process Negative Regulation Of Protein Processing Negative Regulation Of Catalytic Activity Negative Regulation Of Pinocytosis Negative Regulation Of Hydrogen Peroxide Metabolic Process
Tagcloud ?		16s affiliated affiliation alphaproteobacteria antarctic antarctica argentinean assemblage assemblages bacteroides banks betaproteobacteria clones cyanobacteria cytophaga deposited divergent endemic flavobacteriia gammaproteobacteria jubany maritime phylogenetically remarkable richness seawater station summers undescribed
Tagcloud (Difference) ?		16s affiliated affiliation alphaproteobacteria antarctic antarctica argentinean assemblage assemblages bacteroides banks betaproteobacteria clones cyanobacteria cytophaga deposited divergent endemic flavobacteriia gammaproteobacteria jubany maritime phylogenetically remarkable richness seawater station summers undescribed
Tagcloud (Intersection) ?